Sato A, Imaizumi M, Noro T, Ichinohasama R, Saito T, Yoshinari M, Suwabe N, Suzuki H, Koizumi Y, Cui Y
Department of Pediatrics, Tohoku University School of Medicine, Sendai, Japan.
Leuk Res. 1995 Nov;19(11):811-5. doi: 10.1016/0145-2126(95)00065-8.
Phenotypic characteristics of blasts were studied in a Down's infant with transient abnormal myelopoiesis (TAM). Two major subpopulations were identified: (1) CD33+CD42b+ cells with platelet peroxidase activity, the commitment of which to megakaryocytic lineage was supported by an increased expression of GATA-1 mRNA; (2) CD33+CD34+CD7+CD4+ cells with immature ultrastructure, which could be either immature megakaryocytic or myeloid cells with aberrant differentiation. Mixed colonies containing megakaryocytes and monocyte/macrophages in the peripheral blood suggested the presence of progenitors common to these subpopulations. These results may indicate that subpopulations of blasts with phenotypic diversity could be derived from aberrant common progenitors to megakaryocytic and myeloid lineages in this patient.
对一名患有暂时性异常髓系造血（TAM）的唐氏婴儿的原始细胞表型特征进行了研究。鉴定出两个主要亚群：（1）具有血小板过氧化物酶活性的CD33+CD42b+细胞，GATA-1 mRNA表达增加支持其向巨核细胞谱系的定向分化；（2）具有不成熟超微结构的CD33+CD34+CD7+CD4+细胞，其可能是不成熟的巨核细胞或分化异常的髓系细胞。外周血中含有巨核细胞和单核细胞/巨噬细胞的混合集落提示这些亚群存在共同祖细胞。这些结果可能表明，该患者中具有表型多样性的原始细胞亚群可能源自巨核细胞和髓系谱系异常的共同祖细胞。
