产前接触可卡因会影响斯普拉格-道利大鼠的社交行为。
Prenatal cocaine exposure affects social behavior in Sprague-Dawley rats.
作者信息
Johns J M, Noonan L R
机构信息
Brain and Development Research, University of North Carolina at Chapel Hill 27599, USA.
出版信息
Neurotoxicol Teratol. 1995 Sep-Oct;17(5):569-76. doi: 10.1016/0892-0362(95)00017-l.
Abstract
Children prenatally exposed to cocaine are reported to exhibit inappropriate social behavior, including aggression. We have recently observed a similar phenomenon in rats prenatally exposed to cocaine. Pregnant females were injected twice daily with 15 mg/kg cocaine hydrochloride or saline on gestation days 1-20. Offspring were tested for social behavior towards two unfamiliar, untreated rats of the same age and sex. Cocaine-treated males (90 PND) took longer to reciprocate contact and cocaine-treated females (60 PND) spent more time rough grooming unfamiliar females. Male cocaine offspring (180 PND) tested for aggression exhibited an increased frequency and duration and decreased latency to chase an intruder. ACTH was lower in cocaine-treated males (150-180 PND) following plus-maze exposure or exposure to an unfamiliar male. Our data indicate that prenatal cocaine treatment in rats increases fear or aggression responses, dependent on sex and stimulus situation.
摘要
据报道，产前接触可卡因的儿童会表现出不适当的社会行为，包括攻击性。我们最近在产前接触可卡因的大鼠身上也观察到了类似现象。在妊娠第1至20天，对怀孕的雌性大鼠每天注射两次15毫克/千克的盐酸可卡因或生理盐水。对后代进行测试，观察它们对两只年龄和性别相同、未接受过处理的陌生大鼠的社会行为。接受可卡因处理的雄性大鼠（出生后90天）进行互动接触的时间更长，而接受可卡因处理的雌性大鼠（出生后60天）花费更多时间粗暴地梳理陌生雌性大鼠的毛发。对接受可卡因处理的雄性后代（出生后180天）进行攻击性测试时，它们追逐入侵者的频率和持续时间增加，潜伏期缩短。在高架十字迷宫暴露或接触陌生雄性大鼠后，接受可卡因处理的雄性大鼠（出生后150 - 180天）体内促肾上腺皮质激素水平较低。我们的数据表明，大鼠产前接受可卡因处理会增加恐惧或攻击反应，这取决于性别和刺激情境。
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