Claus D, Druschky A, Erbguth F
Department of Neurology, University Erlangen-Nuremberg, Germany.
Mov Disord. 1995 Sep;10(5):574-9. doi: 10.1002/mds.870100508.
Remote adverse effects of local intramuscular botulinum toxin were investigated in a prospective follow-up study. Twenty-six patients with spasmodic torticollis were examined (18 women, eight men, 45 +/- 13 years). Respiratory heart rate variation (HRV) was investigated by a computerized method. Different parameters were recorded (beats per minute, coefficient of variation, root mean square successive difference (RMSSD), spectral analysis, difference and quotient between maximum and minimum RR intervals, mean circular resultant). After one intramuscular injection of 12.5 ng botulinum toxin (Porton Products Ltd., England), no significant influence on HRV was seen. After the second injection, a significant attenuation was seen of four parameters (coefficient of variation, Rmax - Rmin, Rmax divided by Rmin, mean circular resultant) that lasted up to several months. No clinically manifest remote side effects and no cardiac arrhythmia were seen for several months of botulinum toxin treatment. Our investigation proves an effect of local intramuscular botulinum toxin on autonomic cardiac innervation.
在一项前瞻性随访研究中，对局部肌肉注射肉毒杆菌毒素的远程不良反应进行了调查。对26例痉挛性斜颈患者进行了检查（18名女性，8名男性，45±13岁）。采用计算机化方法研究呼吸心率变异性（HRV）。记录了不同参数（每分钟心跳数、变异系数、均方根连续差值（RMSSD）、频谱分析、最大和最小RR间期之间的差值和商、平均圆形结果）。肌肉注射12.5 ng肉毒杆菌毒素（英国Porton Products Ltd.）一次后，未观察到对HRV有显著影响。第二次注射后，观察到四个参数（变异系数、Rmax - Rmin、Rmax除以Rmin、平均圆形结果）有显著衰减，持续长达数月。在肉毒杆菌毒素治疗的几个月中，未观察到临床明显的远程副作用和心律失常。我们的研究证明了局部肌肉注射肉毒杆菌毒素对自主心脏神经支配有影响。
