Rossi M, Matteucci E, Vagheggini G, Ruberti F, Galetta F, Uncini Manganelli C, Fiorelli A, Giampietro O, Giusti C
Cattedra e Scuola di Specializzazione in Medicina Interna, Università degli Studi Pisa.
Minerva Cardioangiol. 1995 Sep;43(9):355-60.
The aim of this study was to evaluate the influence of metabolic control on the development of atherosclerotic lesions in type 1 insulin-dependent diabetic patients (IDDM).
Twenty-eight well controlled IDDM patients, without known risk factors or clinical evidence of cardiovascular disease, together with 28 age-matched healthy controls spontaneously underwent high-resolution echographic evaluation of carotid femoral arteries. A global score of atherosclerotic damage as been assigned to the four investigated vessels on the basis of 1-6 scale, which takes into account most important ultrasound atherosclerotic lesion found in every artery.
Diabetic and healthy controls differed significantly as regard to medio-intimal carotid thickness (p < 0.001), but were similar as for score of atherosclerotic damage.
Our results suggest that, in spite of a carotid wall medio-intimal thickness more pronounced in IDDM patients, well controlled IDDM is associated with atherosclerotic damage almost identical to that of healthy age-matched controls.
本研究的目的是评估代谢控制对1型胰岛素依赖型糖尿病患者（IDDM）动脉粥样硬化病变发展的影响。
28名病情控制良好、无已知危险因素或心血管疾病临床证据的IDDM患者，以及28名年龄匹配的健康对照者，自发接受了颈动脉和股动脉的高分辨率超声检查。根据1 - 6级评分系统，对四条被检查血管的动脉粥样硬化损伤进行整体评分，该评分系统考虑了每条动脉中发现的最重要的超声动脉粥样硬化病变。
糖尿病患者和健康对照者在颈动脉中膜 - 内膜厚度方面存在显著差异（p < 0.001），但在动脉粥样硬化损伤评分方面相似。
我们的结果表明，尽管IDDM患者的颈动脉壁中膜 - 内膜厚度更明显，但病情控制良好的IDDM患者的动脉粥样硬化损伤与年龄匹配的健康对照者几乎相同。
