Frost D, Beischer W
Medizinische Klinik 3, Bürgerhospital Stuttgart.
Dtsch Med Wochenschr. 1994 Sep 16;119(37):1225-30. doi: 10.1055/s-2008-1058825.
In a prospective study high-resolution ultrasonography was used to document any early carotid-artery wall changes (intima-media thickening; plaques), in 165 type I diabetics up to the age of 40 years (66 males, 99 females; mean age 27.5 +/- 6 years; duration of diabetes > 1 year). In two control groups (group 1: 40 with type I diabetes of up to one year's duration; group 2: 20 healthy subjects) the mean intima-media thickness was 0.50 +/- 0.05 and 0.51 +/- 0.06 mm, respectively (maximal value 0.6 mm). In the patients with a longer duration of diabetes it was significantly higher at 0.56 +/- 0.11 mm (P < 0.001). Of the 165 patients with a diabetes duration of more than 1 year, 134 had normal intima-media wall thickness (< 0.6 mm, mean 0.52 +/- 0.07 [group A]), in 15 (group B) it was 0.75 +/- 0.06 mm, and in 16 (group C) there were plaques with a wall thickness of 0.67 +/- 0.15 mm. The incidence of nephropathy and hypertension or hypercholesterolaemia (only in group C) was significantly higher in groups B and C than A (P < 0.01). It is thus clear that these consequential or associated diseases go together, in young type I diabetics, with an increased risk of early arteriosclerosis.
在一项前瞻性研究中，采用高分辨率超声检查记录了165例40岁及以下的I型糖尿病患者（66例男性，99例女性；平均年龄27.5±6岁；糖尿病病程>1年）早期颈动脉壁的任何变化（内膜中层增厚；斑块）。在两个对照组中（第1组：40例病程达1年的I型糖尿病患者；第2组：20例健康受试者），内膜中层平均厚度分别为0.50±0.05和0.51±0.06mm（最大值0.6mm）。糖尿病病程较长的患者内膜中层厚度显著更高，为0.56±0.11mm（P<0.001）。在165例糖尿病病程超过1年的患者中，134例内膜中层壁厚度正常（<0.6mm，平均0.52±0.07[ A组]），15例（B组）为0.75±0.06mm，16例（C组）有斑块，壁厚度为0.67±0.15mm。B组和C组肾病、高血压或高胆固醇血症（仅在C组）的发生率显著高于A组（P<0.01）。因此很明显，在年轻的I型糖尿病患者中，这些并发症或相关疾病与早期动脉硬化风险增加同时存在。
