Cuevas P, Carceller F, Giménez-Gallego G
Servicio de Histología, Hospital Universitario Ramón y Cajal, Madrid, Spain.
Neurosci Lett. 1995 Sep 15;197(3):183-6. doi: 10.1016/0304-3940(95)11926-n.
The death of facial motoneurons after axotomy provides a useful tool for studying neurotrophic factors which could prevent motoneuron loss in vivo. The right facial nerve trunk before the postauricular nerve branching of newborn rats was transected at its extracranial exit, and topically treated, at the axotomy site, with either a vehicle solution containing agarose or sucralfate, or acidic fibroblast growth factor (aFGF). Acidic FGF treatment increased the survival of the facial motoneurons from 18% to 70%. These results suggest that aFGF is a neurotrophic factor for motoneurons in vivo and that this growth factor may provide a new basis for the development of treatments to prevent the loss of damaged motoneurons.
轴突切断术后面部运动神经元的死亡为研究神经营养因子提供了一个有用的工具，这些神经营养因子可以在体内防止运动神经元的损失。新生大鼠耳后神经分支前的右侧面神经干在其颅外出口处被切断，并在轴突切断部位局部用含有琼脂糖或硫糖铝的载体溶液或酸性成纤维细胞生长因子（aFGF）进行处理。酸性FGF治疗使面部运动神经元的存活率从18%提高到70%。这些结果表明，aFGF是体内运动神经元的神经营养因子，并且这种生长因子可能为开发防止受损运动神经元损失的治疗方法提供新的基础。
