Kp1/Ko导致某些凯尔血型组抗原减弱的另一个例子。

A further example of Kp1/Ko exhibiting depression of some Kell group antigens.

作者信息

Ford D S, Knight A E, Smith F

出版信息

Vox Sang. 1977;32(4):220-3. doi: 10.1111/j.1423-0410.1977.tb00633.x.

DOI:10.1111/j.1423-0410.1977.tb00633.x

Abstract

This paper gives details of a family in which there are numerous examples of the heterozygous Kdegree state. The study was initiated by the presence of anti-Kpb in the serum of the propositus. Reactions with anti-K, anti-Ku, anti-Jsb and anti-K13 confirm that the Kdegree gene in trans with Kpa results in weaker expression of these Kell antigens. One example of anti-K showed some evidence of dosage effect with kKpb/Kdegree cells, but these results were not confirmed by quantitation studies.

摘要

本文详细介绍了一个家族，其中有许多杂合Kdegree状态的实例。该研究由先证者血清中抗Kpb的存在引发。与抗K、抗Ku、抗Jsb和抗K13的反应证实，与Kpa处于反式的Kdegree基因会导致这些凯尔抗原的表达减弱。一个抗K的实例显示，在kKpb/Kdegree细胞中存在一些剂量效应的证据，但定量研究未证实这些结果。