Jung S H, Wieand S, Cha S S
Division of Biostatistics, Mayo Clinic, Rochester, MN 55905, USA.
Stat Med. 1995 Oct 30;14(20):2217-25. doi: 10.1002/sim.4780142005.
A proliferation of biologic markers has led to increased interest in methods for comparing the prognostic value of markers in predicting time to recurrence of or death from disease. This paper proposes a nonparametric test statistic for comparing two continuous markers when the outcome of interest is time to an event and the outcome is subject to right censoring. Results from Monte Carlo studies show that the new testing procedure is reliable for practical use. We present an example in which we use the statistic successfully in a colon cancer study to select between two potentially useful markers.
生物标志物的大量涌现使得人们对比较标志物在预测疾病复发时间或死亡时间方面的预后价值的方法越来越感兴趣。本文提出了一种非参数检验统计量，用于比较两个连续标志物，此时感兴趣的结果是事件发生时间且结果存在右删失。蒙特卡罗研究结果表明，新的检验程序在实际应用中是可靠的。我们给出一个例子，其中我们在一项结肠癌研究中成功地使用该统计量在两个潜在有用的标志物之间进行选择。
