Khan S R
Department of Pathology, College of Medicine University of Florida, Gainesville 32610-0275, USA.
Scanning Microsc. 1995 Mar;9(1):89-100; discussion 100-1.
Calcium oxalate nephrolithiasis in rats requires induction of hyperoxaluria which results in increased urinary calcium oxalate supersaturation. As a result of low to mild chronic hyperoxaluria, calcium oxalate crystals deposit first in the papillary collecting ducts. Crystal deposition in the kidneys is preceded by calcium oxalate crystalluria and starts with the retention of aggregated calcium oxalate crystals in the renal tubules. Retained crystals move from the tubules to the interstitium, and in the process, become anchored to the tubular basement membrane. Crystal aggregates present in the superficial peripheral collecting ducts of the renal papillae ulcerate through to the papillary surface and grow into the stones.
大鼠草酸钙肾结石的形成需要诱导高草酸尿症，这会导致尿草酸钙过饱和度增加。由于低至轻度的慢性高草酸尿症，草酸钙晶体首先沉积在乳头集合管中。肾结石的形成之前会出现草酸钙结晶尿，且始于肾小管中聚集的草酸钙晶体的潴留。潴留的晶体从肾小管移动到间质，在此过程中，会附着于肾小管基底膜。肾乳头浅表外周集合管中存在的晶体聚集体会溃疡至乳头表面并长成结石。
