Lembeck F, Beubler E, Lepuschütz H F, Stolze A
Wien Klin Wochenschr. 1977 Apr 15;89(8):257-60.
Plasmapheresis is a method used to eliminate toxic substances with high plasma protein-binding properties. Poisoning by strongly plasma protein-binding substances cannot be treated by haemodialysis or peritoneal dialysis. Hence, an attempt was made to hasten the elimination of phenylbutazone, a suitable model substance (plasma protein binding affinity 98%), by plasmapheresis. Some of the experiments were performed with oxygen under high pressure (OHP). A singly plasmapheresis of the total blood volume or triple plasmapheresis of half of the blood volume, performed at 20 min intervals accelerated the elimination of phenylbutazone significantly and all animals survived. A single plasmapheresis of the threefold blood volume had the greatest effect in lowering the concentration of phenylbutazone in the blood, but only one of three animals survived. OHP had no influence on the half-life of phenylbutazone and did not increase the survival rate.
血浆置换是一种用于清除具有高血浆蛋白结合特性的有毒物质的方法。由强血浆蛋白结合物质引起的中毒不能通过血液透析或腹膜透析治疗。因此，人们尝试通过血浆置换来加速消除苯丁唑酮，一种合适的模型物质（血浆蛋白结合亲和力为98%）。一些实验是在高压氧（OHP）下进行的。以20分钟的间隔进行全血容量的单次血浆置换或一半血容量的三次血浆置换，可显著加速苯丁唑酮的清除，所有动物均存活。三倍血容量的单次血浆置换对降低血液中苯丁唑酮的浓度效果最佳，但三只动物中只有一只存活。高压氧对苯丁唑酮的半衰期没有影响，也没有提高存活率。
