[Plasma perfusion in life-threatening exogenous poisoning].

Since 1984 30 patients with severe exogenous intoxications have been treated by plasma perfusion. This method has advantages compared to other instrumental detoxification techniques, especially hemoperfusion; i.e. no loss of blood cells, no necessity for systemic anticoagulation and no blockage of the adsorber by thrombus. The plasma, which was obtained by plasma separation, perfused the respective adsorber (activated charcoal, resin). After "purification" the plasma was returned to the patient. The mean perfused plasma volume amounted to 3800 ml per patient and per treatment cycle. 27 of the 30 patients were treated successfully. The observed toxokinetic data confirmed the effectiveness of plasma perfusion in the elimination of toxic substances.