Berning T, Krummenerl T, Glaser J, Paulus H, Gerlach U
Medizinischen Klinik und Poliklinik der Westfälischen Wilhelms-Universität Münster, Abteilung Innere Medizin B.
Schweiz Med Wochenschr. 1987 Sep 12;117(37):1368-73.
Since 1984 30 patients with severe exogenous intoxications have been treated by plasma perfusion. This method has advantages compared to other instrumental detoxification techniques, especially hemoperfusion; i.e. no loss of blood cells, no necessity for systemic anticoagulation and no blockage of the adsorber by thrombus. The plasma, which was obtained by plasma separation, perfused the respective adsorber (activated charcoal, resin). After "purification" the plasma was returned to the patient. The mean perfused plasma volume amounted to 3800 ml per patient and per treatment cycle. 27 of the 30 patients were treated successfully. The observed toxokinetic data confirmed the effectiveness of plasma perfusion in the elimination of toxic substances.
自1984年以来，30例严重外源性中毒患者接受了血浆灌注治疗。与其他器械解毒技术，尤其是血液灌注相比，这种方法具有优势；即不损失血细胞，无需全身抗凝，吸附器也不会被血栓阻塞。通过血浆分离获得的血浆灌注相应的吸附器（活性炭、树脂）。“净化”后，血浆回输给患者。每位患者每个治疗周期的平均灌注血浆量为3800毫升。30例患者中有27例治疗成功。观察到的毒物动力学数据证实了血浆灌注在清除有毒物质方面的有效性。
