Lageder H, Irsigler K, Schneider W H, Spona J, Bauer P, Wohlzogen F X
Wien Klin Wochenschr. 1977 Apr 15;89(8):276-81.
A low-dosage combination type of contraceptive (oestrogen-gestagen) was given to 19 metabolically- healthy women of normal weight over a period of 6 months. Glucose tolerance, serum insulin and serum lipids were measured 1 month before, during and 2 months after medication. There was a slight decrease in the basal insulin values and an opposite trend in the basal blood glucose values, not exceeding 10 mg% in comparison to pretreatment values. The oral glucose tolerance test with a load of 100 g oligosaccharides did not show any statiscally significant changes during the 9 month observation period. The serum insulin curve, however, showed a delayed increase with a tendency to return to original values after medication had stopped. A slight degree of insulin resistance without change in glucose tolerance can, therefore, be assumed. There was a tendency for triglyceride values to increase over the observation period. A trend towards decreased cholesterol, on the other hand, was statistically insignificant. The observed changes were all within the normal range in all cases.
对19名体重正常、代谢健康的女性给予低剂量复方避孕药（雌激素 - 孕激素），为期6个月。在用药前1个月、用药期间及停药后2个月测量葡萄糖耐量、血清胰岛素和血脂。基础胰岛素值略有下降，基础血糖值呈相反趋势，与治疗前值相比不超过10mg%。在9个月的观察期内，口服100g低聚糖负荷的葡萄糖耐量试验未显示任何统计学上的显著变化。然而，血清胰岛素曲线显示上升延迟，停药后有恢复到原始值的趋势。因此，可以假定存在轻度胰岛素抵抗但葡萄糖耐量无变化。在观察期内甘油三酯值有升高趋势。另一方面，胆固醇降低的趋势在统计学上无显著意义。所有情况下观察到的变化均在正常范围内。
