Spellacy W N, Birk S A, Buggie J, Buhi W C
J Reprod Med. 1981 Jun;26(6):295-8.
Three-hour oral glucose tolerance tests were done before and after one year of use of a low-estrogen-type oral contraceptive (OC) in 14 women. The drug contained 0.035 mg ethinyl estradiol and 0.4 mg norethindrone. Both blood glucose and plasma insulin were measured. During the year there were no significant changes in the subjects' weights, whereas their blood pressures decreased. The results showed a significance decrease in the fasting blood glucose level after one year for women with a "normal" control test while the remainder of the values remained unchanged. For women with a "borderline" abnormal control test there was a significant decrease in the two-hour glucose level. There were no significant changes in the plasma insulin levels. These results confirm that this low-estrogen-type oral contraceptive produces minimal changes in the carbohydrate metabolism of users.
对14名女性在使用低雌激素型口服避孕药（OC）一年前后进行了三小时口服葡萄糖耐量试验。该药物含有0.035毫克乙炔雌二醇和0.4毫克炔诺酮。同时测量了血糖和血浆胰岛素。在这一年中，受试者的体重没有显著变化，而她们的血压有所下降。结果显示，“正常”对照试验的女性在一年后空腹血糖水平显著降低，而其余值保持不变。对于“临界”异常对照试验的女性，两小时血糖水平显著降低。血浆胰岛素水平没有显著变化。这些结果证实，这种低雌激素型口服避孕药对使用者的碳水化合物代谢产生的变化最小。
