Mel'nychuk S D, Rohovs'kyĭ S P, Mel'nychuk D O
Ukr Biokhim Zh (1978). 1995 Jul-Aug;67(4):67-75.
Experiments on rats have shown an important role of hypercapnia in the development of condition of artificial hibernation in combination with influence of hypothermia, hypoxia and hypercapnia. It is proved that the joint action of hypothermia, hypoxia and hypercapnia has induced development of respiratory acidosis and hibernation in animals, while removal of the hypercapnia effect has induced development of acute metabolic acidosis and death of animals. It has been found that animals in the state of artificial hibernation have considerable changes in concentrations of main electrolytes (Na+, K+, Ca+, Mg2+, phosphates, Cl-) and metabolites (NH3, glutamine, urea) in blood as well as in activity of enzymes (glutamaldehydrogenase, glutaminase, arginase) in tissues of the liver and kidneys.
对大鼠的实验表明，在低温、缺氧和高碳酸血症的共同影响下，高碳酸血症在人工冬眠状态的发展中起着重要作用。事实证明，低温、缺氧和高碳酸血症的联合作用可诱发动物呼吸性酸中毒和冬眠，而消除高碳酸血症的影响则可诱发急性代谢性酸中毒和动物死亡。研究发现，处于人工冬眠状态的动物血液中主要电解质（Na+、K+、Ca+、Mg2+、磷酸盐、Cl-）和代谢产物（NH3、谷氨酰胺、尿素）的浓度以及肝脏和肾脏组织中酶（谷氨酸脱氢酶、谷氨酰胺酶、精氨酸酶）的活性都有显著变化。
