Icenogle J P, Clancy K A, Lin S Y
Human Papillomavirus Section, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.
Virology. 1995 Dec 20;214(2):664-9. doi: 10.1006/viro.1995.0082.
The sequences of the capsid genes of a human papillomavirus type 16 (HPV 16) DNA and an HPV 31 DNA were determined. The HPV 16 DNA contained genes coding for the most variable HPV 16 capsid proteins yet identified (17 variable amino acids). Three of six coding changes in the HPV 31 DNA occurred at positions equivalent to ones where variable amino acids in HPV 16 have been observed. Variable amino acids in both viruses occurred predominantly in regions which showed amino acid variation when closely related types of HPV were compared; thus, most of the factors which determined the intratypic variation in the capsid proteins of the viruses described here were likely the same as those which determined differences between the capsid proteins of different HPV types.
测定了16型人乳头瘤病毒（HPV 16）DNA和HPV 31 DNA的衣壳基因序列。HPV 16 DNA包含编码迄今所鉴定出的最具变异性的HPV 16衣壳蛋白的基因（17个可变氨基酸）。HPV 31 DNA的六个编码变化中有三个发生在与HPV 16中观察到可变氨基酸的位置相当的位置。两种病毒中的可变氨基酸主要出现在比较密切相关的HPV类型时显示氨基酸变异的区域；因此，决定此处所述病毒衣壳蛋白型内变异的大多数因素可能与决定不同HPV类型衣壳蛋白差异的因素相同。
