Mendzheritskiĭ A M, Uskova N I, Lysenko A V, Matsionis A E, Sametskiĭ E A
Vopr Med Khim. 1995 Sep-Oct;41(5):16-9.
The GABAergic system was adequate altered after simultaneous use of delta-sleeping peptide and piracetam in intact animals: gamma-butyric acid was accumulated unidirectionally by inhibiting brain glutamate decarboxylase activity. Administration of the peptide caused a slight decrease in the levels of aspartic acid, while piracetam contributed to a marked accumulation of the amino acid. The antistressor and adaptive effects of each drug were augmented if they were given simultaneously before acute emotional stress developed in the animals during one-hour hypokinesia; these effects were expressed as stabilized balance of inhibitory and excitatory neurotransmitter amino acids.
在未受损动物中同时使用δ-睡眠肽和吡拉西坦后，GABA能系统发生了适度改变：通过抑制脑谷氨酸脱羧酶活性，γ-丁酸单向积累。给予该肽导致天冬氨酸水平略有下降，而吡拉西坦则导致该氨基酸显著积累。如果在动物1小时运动减退期间急性情绪应激发生之前同时给予每种药物，其抗应激和适应性作用会增强；这些作用表现为抑制性和兴奋性神经递质氨基酸的平衡稳定。
