Degré M, Bukholm G
Kaptein W. Wilhelmsen og frues Bakteriologiske Instiutt, Rikshospitalet, University of Oslo, Norway.
J Biol Regul Homeost Agents. 1995 Jan-Mar;9(1):15-20.
Intragastrically inoculated Salmonella typhimurium produces a systemic infection in mice with high mortality. We have examined the effect of interferon (IFN)-gamma and tumor necrosis factor (TNF)-alpha on the development of the disease. IFN-gamma reduced penetration of bacteria into the gut epithelial cells, reduced the development of bacteremia, reduced mortality and prolonged the length of survival of mice both after peroral and after intraperitoneal administration. On the other hand TNF-alpha had a similar effect only when given intraperitoneally but not by peroral route. These findings indicate that the mechanisms by which these two cytokines influence the development of S. typhimurium infection are different. This is the first observation that perorally administered cytokines may have local and systemic effects on bacterial infection.
经胃内接种的鼠伤寒沙门氏菌可在小鼠中引发具有高死亡率的全身感染。我们已经研究了干扰素（IFN）-γ和肿瘤坏死因子（TNF）-α对该疾病发展的影响。IFN-γ减少了细菌向肠道上皮细胞的渗透，降低了菌血症的发展，降低了死亡率，并在经口和腹腔注射后均延长了小鼠的存活时间。另一方面，TNF-α仅在腹腔注射时具有类似作用，经口给药则无此作用。这些发现表明这两种细胞因子影响鼠伤寒沙门氏菌感染发展的机制不同。这是首次观察到经口给药的细胞因子可能对细菌感染产生局部和全身作用。
