Oh J K, Gibbons R J, Christian T F, Gersh B J, Click R L, Sitthisook S, Tajik A J, Seward J B
Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Am Heart J. 1996 Jan;131(1):32-7. doi: 10.1016/s0002-8703(96)90047-2.
Twenty patients (13 men and 7 women; mean age 61 +/- 12 years) with > 30 minutes chest pain and new ST-segment elevation who were treated with reperfusion therapy underwent technetium 99m sestamibi imaging and two-dimensional echocardiography simultaneously before and within 2 hours of each test after acute reperfusion therapy. Nine patients had anterior wall myocardial infarction. Fifteen patients were initially treated with intravenous thrombolytic agents, and five patients underwent urgent percutaneous transluminal coronary angioplasty. Both myocardial perfusion defect and wall motion score index (WMSI) improved after reperfusion therapy (perfusion defect from 28% to 15%, WMSI from 1.68 to 1.45, respectively; p < 0.005). The overall correlation between WMSI and perfusion defect as a measure of myocardium at risk was significant during the acute phase (r = 0.71) and at hospital dismissal (r = 0.71). Thus myocardial perfusion defect and wall motion abnormalities correlated fairly well in patients with acute myocardial infarction during the acute phase and at predismissal study.
20例（13例男性和7例女性；平均年龄61±12岁）出现胸痛超过30分钟且有新的ST段抬高并接受再灌注治疗的患者，在急性再灌注治疗前及每次检查后2小时内同时接受了锝99m甲氧基异丁基异腈显像和二维超声心动图检查。9例患者发生前壁心肌梗死。15例患者最初接受静脉溶栓治疗，5例患者接受了紧急经皮冠状动脉腔内血管成形术。再灌注治疗后心肌灌注缺损和室壁运动评分指数（WMSI）均有所改善（灌注缺损分别从28%降至15%，WMSI从1.68降至1.45；p<0.005）。在急性期（r = 0.71）和出院时（r = 0.71），作为评估危险心肌指标的WMSI与灌注缺损之间的总体相关性均显著。因此，在急性期和出院前研究中，急性心肌梗死患者的心肌灌注缺损与室壁运动异常相关性相当好。
