Cubilla A L, Ayala M T, Barreto J E, Bellasai J G, Nöel J C
Department of Pathology, Facultad de Ciencias Médicas, Universidad Nacional de Asunción, Paraguay.
Am J Surg Pathol. 1996 Feb;20(2):156-60. doi: 10.1097/00000478-199602000-00003.
Three patients, aged 37, 72, and 74 years, with adenosquamous carcinoma of the penis are described. The duration of disease was 6, 9, and 144 months, respectively. Grossly a firm, white-gray granular exophytic mass was noted (7.6 cm average diameter). Microscopically, a mixed carcinoma showing squamous and glandular elements was present; the squamous component predominated. In two cases the adenocarcinoma was located in the perimeatal area of the glans. The periurethral glands were not involved. The glandular foci were discrete and had minimal admixture with the squamous carcinoma. Mucin material was present in the lumina, apical border, and cytoplasm. Immunohistochemically, cells showed positivity for carcinoembryonic antigen in glandular areas. The squamous cell carcinomas were of the "warty" variant in two cases and of the usual squamous cell type in the other case. In one patient, metastatic adenosquamous carcinoma was noted in one inguinal node and showed mucin secretion. This patient is alive and well 102 months after diagnosis. Another patient is alive with no evidence of disease 12 months after surgery, and the third was lost to follow-up. Adenosquamous carcinomas of the penis are unusual neoplasms probably originating in penile surface epithelium and in embryologically misplaced mucus glands of the perimeatal region of glans mucosa.
本文描述了3例阴茎腺鳞癌患者，年龄分别为37岁、72岁和74岁。病程分别为6个月、9个月和144个月。大体检查可见一个坚实的灰白色颗粒状外生性肿物（平均直径7.6 cm）。显微镜下可见一个混合性癌，同时显示鳞状和腺性成分，其中鳞状成分占主导。2例腺癌位于龟头尿道口周围区域，尿道周围腺体未受累。腺性病灶分散，与鳞状癌的混合极少。管腔、顶端边界和细胞质中均有黏液物质。免疫组化显示，腺性区域的细胞癌胚抗原呈阳性。2例鳞状细胞癌为“疣状”变异型，另1例为普通鳞状细胞型。1例患者的一个腹股沟淋巴结出现转移性腺鳞癌，并显示黏液分泌。该患者在诊断后102个月仍存活且状况良好。另1例患者术后12个月存活，无疾病证据，第3例失访。阴茎腺鳞癌是一种罕见的肿瘤，可能起源于阴茎表面上皮以及龟头黏膜尿道口周围区域胚胎期错位的黏液腺。
