Yamamoto M, Hibi H, Katsuno S, Miyake K
Department of Urology, Nagoya University School of Medicine, Japan.
Arch Androl. 1995 Jul-Aug;35(1):49-55. doi: 10.3109/01485019508987853.
The authors treated 135 men who underwent varicocelectomy, but had sustained Leydig cell dysfunction disclosed by LHRH test with human chorionic gonadotropin (hCG). hCG was administered for 10 weeks: 50,000 units were given in 10 divided doses intramuscularly. Semen analysis and measurement of serum hormone level were obtained 8 weeks after the completion of treatment, and every 3 months after that. All patients were followed up for 2 years to confirm pregnancy. Fifty-five percent of patients achieved pregnancy and they showed significant increase in sperm density, percentage of sperm motility, normal form sperm, and serum testosterone level. It is recommended that hCG be administered to patients who undergo varicocelectomy but have persistent subtle Leydig cell dysfunction disclosed by LHRH test to stimulate the intratesticular testosterone production.
作者对135例接受精索静脉曲张切除术但经促黄体生成素释放激素（LHRH）试验显示存在莱迪希细胞功能障碍的男性患者使用人绒毛膜促性腺激素（hCG）进行治疗。hCG给药10周：50000单位分10次肌肉注射。治疗结束8周后以及此后每3个月进行精液分析和血清激素水平测定。所有患者随访2年以确认妊娠情况。55%的患者成功妊娠，且其精子密度、精子活力百分比、正常形态精子以及血清睾酮水平均显著增加。建议对接受精索静脉曲张切除术但经LHRH试验显示存在持续性轻微莱迪希细胞功能障碍的患者给予hCG，以刺激睾丸内睾酮的生成。
