Struzyna J, Pojda Z, Braun B, Chomicka M, Sobiczewska E, Wrembel J
Department of Burn Treatment and Reconstructive Surgery, Institute of Surgery CSK WAM, Warsaw, Poland.
Burns. 1995 Sep;21(6):437-40. doi: 10.1016/0305-4179(95)00018-7.
The presence and concentration of selected cytokines (interleukin 4 (IL-4), interleukin 6 (IL-6), interleukin 8 (IL-8), granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) were evaluated in the sera of 12 burned patients (6-90 per cent body surface area). The presence of cytokines in the sera of 20 healthy volunteers (control group) was always undetectable (< 2 pg/ml). In sera of the burned patients the concentrations of IL-4 or GM-CSF were also below the test sensitivity levels, while G-CSF and IL-6 were present throughout all the observation period and IL-8 was detectable at the onset of massive infections. The serum concentrations of G-CSF and IL-6 increased during the episodes of clinically and bacteriologically detectable infections. Their increases were, however, observable 12-24 h later than the other infection symptoms. Similar increases in G-CSF and IL-6 levels have been detected during corrective surgery (covering of granulation tissue with skin grafts). It may be concluded that serum G-CSF and IL-6 levels in burned patients may be considered as diagnostic factors, but the delays in the reaction to the massive infection do not allow us to use them for predicting the time of onset of the infection.
对12名烧伤患者（烧伤面积为6%-90%）的血清进行检测，评估特定细胞因子（白细胞介素4（IL-4）、白细胞介素6（IL-6）、白细胞介素8（IL-8）、粒细胞集落刺激因子（G-CSF）和粒细胞巨噬细胞集落刺激因子（GM-CSF））的存在情况及浓度。20名健康志愿者（对照组）血清中细胞因子的存在情况始终无法检测到（<2 pg/ml）。在烧伤患者的血清中，IL-4或GM-CSF的浓度也低于检测灵敏度水平，而G-CSF和IL-6在整个观察期内均有存在，IL-8在大规模感染开始时可检测到。在临床和细菌学可检测到的感染发作期间，G-CSF和IL-6的血清浓度升高。然而，它们升高的时间比其他感染症状晚12-24小时。在矫正手术（用皮肤移植覆盖肉芽组织）期间也检测到G-CSF和IL-6水平有类似升高。可以得出结论，烧伤患者血清中的G-CSF和IL-6水平可被视为诊断因素，但对大规模感染反应的延迟使我们无法用它们来预测感染的发作时间。
