Wilson A, Brooks D C, Bouton M E
Department of Psychology, University of Vermont, Burlington 05405, USA.
Behav Neurosci. 1995 Oct;109(5):828-36. doi: 10.1037//0735-7044.109.5.828.
The effect of fornix lesions on some effects of manipulating the context on performance in extinction were studied. In renewal, subjects' responding to an extinguished conditioned stimulus (CS) recovered when the CS was presented in the context in which it had been conditioned after extinction in a different context. In reinstatement, it recovered when the CS was tested after independent presentation of the unconditioned stimulus (US; an effect mediated by contextual conditioning.) In spontaneous recovery, it recovered after the passage of time, that is, when the CS was tested in a new temporal context. In the conditioned suppression method, fornix lesions had no effect on conditioning, extinction, renewal, or spontaneous recovery; however, they abolished the reinstatement effect. The results suggest that the hippocampal system may be important in the formation of context-US associations, but not in other types of learning about the context.
研究了穹窿损伤对在消退过程中操纵情境对行为表现的某些影响。在恢复阶段，当在不同情境中进行消退后，将条件刺激（CS）呈现于其最初被条件化的情境中时，受试者对已消退的条件刺激的反应会恢复。在恢复原状阶段，当在独立呈现无条件刺激（US；一种由情境条件化介导的效应）后对CS进行测试时，反应会恢复。在自发恢复阶段，经过一段时间后反应会恢复，也就是说，当在新的时间情境中对CS进行测试时。在条件性抑制方法中，穹窿损伤对条件化、消退、恢复或自发恢复没有影响；然而，它们消除了恢复原状效应。结果表明，海马系统可能在情境-US关联的形成中很重要，但在其他类型的情境学习中并非如此。
