Mai T V, Selby A M, Simpson J M, Isaacs D
Department of Immunology and Infectious Diseases, Royal Alexandra Hospital for Children, Camperdown, New South Wales, Australia.
J Paediatr Child Health. 1995 Oct;31(5):465-8. doi: 10.1111/j.1440-1754.1995.tb00859.x.
To determine whether simple clinical parameters could be used to predict the severity of acute bronchiolitis and the need for supplemental oxygen therapy.
A prospective study, performed in a tertiary care paediatric hospital. Seventy-one infants under 15 months of age with a clinical diagnosis of acute bronchiolitis were examined on admission. Clinical parameters were recorded, and each infant was re-examined after approximately 12 and 24 h. All infants were examined by one medical student and, when possible, by a doctor, the two being unaware of each other's findings. Parameters recorded included respiratory and heart rates and presence of wheeze, crackles, intercostal recession, sternal retraction and/or cyanosis. The outcome measure was the need for supplemental oxygen, as determined by the independent caring medical team, on the basis of pulse oximetry and clinical judgement.
Forty (56%) of the 71 babies required supplemental oxygen. All cyanosed babies required supplemental oxygen, but only 9 (21%) were cyanosed on admission. Intercostal recession (relative risk RR 2.55; 95% CI 1.28, 5.08) and sternal retraction (RR 1.60; 95% CI 1.06, 2.42) predicted the need for supplemental oxygen with moderate accuracy. Interobserver agreement was only fair for most parameters, but was poor for intercostal recession and good for cyanosis.
Simple clinical parameters may help predict the need for oxygen therapy in acute bronchiolitis, although further studies are required to define suitable clinical criteria. Such criteria are extremely important in developing countries where oxygen is a scarce resource.
确定简单的临床参数是否可用于预测急性细支气管炎的严重程度以及是否需要补充氧气治疗。
在一家三级儿科医院进行的前瞻性研究。对71名15个月以下临床诊断为急性细支气管炎的婴儿入院时进行检查。记录临床参数,每名婴儿在大约12小时和24小时后再次接受检查。所有婴儿均由一名医学生检查,如有可能,由一名医生检查,两人均不知对方的检查结果。记录的参数包括呼吸频率、心率以及是否存在喘息、啰音、肋间凹陷、胸骨退缩和/或发绀。结局指标是由独立的护理医疗团队根据脉搏血氧饱和度测定法和临床判断确定的是否需要补充氧气。
71名婴儿中有40名(56%)需要补充氧气。所有发绀的婴儿都需要补充氧气,但入院时仅有9名(21%)发绀。肋间凹陷(相对危险度RR 2.55;95%可信区间1.28,5.08)和胸骨退缩(RR 1.60;95%可信区间1.06,2.42)对预测是否需要补充氧气具有中等准确性。观察者间对大多数参数的一致性仅为一般,但对肋间凹陷的一致性较差,对发绀的一致性良好。
简单的临床参数可能有助于预测急性细支气管炎患者是否需要氧气治疗,不过还需要进一步研究来确定合适的临床标准。在氧气资源稀缺的发展中国家,这样的标准极其重要。