Singer K, Edmondston S, Day R, Breidahl P, Price R
Department of Diagnostic Radiology, Royal Perth Hospital, Western Australia.
Bone. 1995 Aug;17(2):167-74. doi: 10.1016/s8756-3282(95)00165-4.
The bone density of thoracolumbar vertebral columns (T1 to L5) from 18 individuals was measured using quantitative computed tomography and dual energy x-ray absorptiometry. Three hundred six isolated vertebral bodies were tested in a materials test device to determine their compressive strength. Between T1 and L5 the mean segmental increase in bone mineral content was 0.3 g, while the corresponding mean decrease in trabecular density was 4.7 HU. Midvertebral body cross-sectional area increased by an average of 46 mm2 per segment and the mean segmental increase in compressive strength was 0.17 kN. Compressive strength was significantly correlated with bone mineral density measured with dual energy x-ray absorptiometry (r = 0.86). Vertebral trabecular density samples measured with quantitative computed tomography were poorly correlated with compressive strength (r = 0.28); however, this was improved when the trabecular density was multiplied by the midvertebral body cross-sectional area (r = 0.83). This study provides information concerning the relationships between density and mechanical properties of all thoracic and lumbar vertebral bodies across a wide age range. While the load-bearing capacity of the vertebral bodies is largely dependent on their geometry and bone density, this relationship has been only extensively tested for the lumbar spine. This study extends these observations over the lumbar and thoracic regions to provide a comprehensive analysis of the strength characteristics of each vertebral body. This is particularly important given the paucity of data on the thoracic spine where age-related vertebral fractures predominate. These data provide a basis for the development of models to predict the potential for thoracolumbar fractures in the elderly vertebral column.
使用定量计算机断层扫描和双能X线吸收法测量了18名个体胸腰椎（T1至L5）的骨密度。在材料测试装置中对306个孤立椎体进行测试，以确定其抗压强度。在T1和L5之间，骨矿物质含量的平均节段性增加为0.3克，而小梁密度相应的平均降低为4.7HU。椎体中部横截面积平均每个节段增加46平方毫米，抗压强度的平均节段性增加为0.17千牛。抗压强度与双能X线吸收法测量的骨矿物质密度显著相关（r = 0.86）。定量计算机断层扫描测量的椎体小梁密度样本与抗压强度的相关性较差（r = 0.28）；然而，当小梁密度乘以椎体中部横截面积时，相关性得到改善（r = 0.83）。本研究提供了关于广泛年龄范围内所有胸腰椎椎体密度与力学性能之间关系的信息。虽然椎体的承载能力在很大程度上取决于其几何形状和骨密度，但这种关系仅在腰椎进行了广泛测试。本研究将这些观察结果扩展到腰椎和胸椎区域，以全面分析每个椎体的强度特征。鉴于胸椎数据匮乏，而与年龄相关的椎体骨折在胸椎中占主导地位，这一点尤为重要。这些数据为开发预测老年椎体胸腰椎骨折可能性的模型提供了基础。
