Konermann W, Stubbe F, Link T, Meier N
Orthopädische Klinik Hessisch Lichtenau.
Z Orthop Ihre Grenzgeb. 1999 May-Jun;137(3):223-31. doi: 10.1055/s-2008-1037398.
This study analyzed the correlation between the compressive strength of human thoracolumbar vertebrae, bone density and endplate area (measured by SE-QCT).
The compressive strength of 110 human vertebral specimens (D11-L5) was measured. In order to determine standard values for human vertebral specimens from each level and different female and male age groups were examined. Before biomechanical testing the specimens were examined using SE-QCT with 1.5 and 10 mm slice thickness. Three different slice locations (mid-vertebral and adjacent to both endplates) and 6 regions of interest (ROI) were chosen to assess BMD. The area of the vertebral endplates was measured by CT.
Highest correlations between BMD and compressive strength were found for the 10 mm thick midvertebral slices with a small ellipsoid ROI. Cancellous and cortical bone contributed to the compressive strength to the same amount. Compressive strength and endplate area increased in the cranio-caudal direction, bone density was constant throughout thoracolumbar spine. Bone density and compressive strength depended on age and sex. Compressive strength of human thoracolumbar vertebrae increased with bone density as well as the size of the endplates.
Using bone density and endplate area (SE-QCT) of human thoracolumbar vertebrae (D11-L5) a prediction of compressive strength is possible with an error of estimation of 1.17 kN and a correlation factor of 0.85. The prediction of the compressive strength allows an estimation of the risk of vertebral fracture, i.e. in patients with osteoporosis or in individuals with intensive physical activities. The standard values of the human thoracolumbar vertebrae together with biomechanical examinations of vertebral metastases can be used to estimate the compressive strength of osteolytic and osteoplastic spinal metastases.
本研究分析了人胸腰椎椎体抗压强度、骨密度与终板面积（通过SE-QCT测量）之间的相关性。
测量了110个人类椎体标本（D11-L5）的抗压强度。为了确定各椎体水平以及不同性别和年龄组人类椎体标本的标准值，对其进行了检查。在进行生物力学测试之前，使用1.5毫米和10毫米层厚的SE-QCT对标本进行检查。选择三个不同的切片位置（椎体中部以及靠近两个终板处）和6个感兴趣区域（ROI）来评估骨密度。通过CT测量椎体终板的面积。
对于10毫米厚的椎体中部切片以及小椭圆形ROI，发现骨密度与抗压强度之间的相关性最高。松质骨和皮质骨对抗压强度的贡献相同。抗压强度和终板面积在头-尾方向上增加，胸腰椎的骨密度在整个脊柱中保持恒定。骨密度和抗压强度取决于年龄和性别。人胸腰椎椎体的抗压强度随骨密度以及终板大小的增加而增加。
利用人胸腰椎（D11-L5）的骨密度和终板面积（SE-QCT），可以预测抗压强度，估计误差为1.17 kN，相关系数为0.85。抗压强度的预测有助于估计椎体骨折的风险，例如骨质疏松患者或从事高强度体力活动的个体。人胸腰椎的标准值以及椎体转移瘤的生物力学检查可用于估计溶骨性和成骨性脊柱转移瘤的抗压强度。
