Fotiades J, Lim H W, Jiang S B, Soter N A, Sanchez M, Moy J
Ronald O. Perelman Department of Dermatology, New York University School of Medicine, NY 10016, USA.
Photodermatol Photoimmunol Photomed. 1995 Jun;11(3):107-11. doi: 10.1111/j.1600-0781.1995.tb00148.x.
To evaluate the efficacy of ultraviolet B (UVB) phototherapy for the treatment of psoriasis in patients infected with human immunodeficiency virus (HIV), the response of 14 patients was compared to that of matched seronegative control individuals. All patients were evaluated prior to treatment (baseline) and after 21 treatments for the extent of total body surface area (TBSA) involvement and the quantification of scale, erythema, and thickness of plaques using a scale of 0 (absent) to 4 (severe). The only concomitant medication allowed was salicylic acid in petrolatum. The cumulative score for scale, erythema, and thickness improved 1.9 +/- 0.5 [mean +/- standard error of mean (SEM)] in the HIV group and 2.4 +/- 0.3 in controls. There was 40.9 +/- 7.3% reduction of TBSA involvement in the former and 38.4 +/- 7.6% reduction in the latter group. None of the differences was statistically significant. There was no statistically significant difference in the response to therapy among various stages of immunosuppression in the HIV group. There was also no deterioration of immune status in this group. UVB phototherapy is an effective treatment for psoriasis in patients infected with HIV. The response is identical to that of matched control individuals.
为评估紫外线B（UVB）光疗对感染人类免疫缺陷病毒（HIV）的银屑病患者的疗效，将14例患者的反应与配对的血清学阴性对照个体进行比较。所有患者在治疗前（基线）以及接受21次治疗后，均使用0（无）至4（严重）的量表对全身表面积（TBSA）受累程度以及鳞屑、红斑和斑块厚度进行量化评估。唯一允许同时使用的药物是凡士林水杨酸。HIV组的鳞屑、红斑和厚度累积评分改善了1.9±0.5[平均值±平均标准误差（SEM）]，对照组为2.4±0.3。前一组TBSA受累减少了40.9±7.3%，后一组减少了38.4±7.6%。这些差异均无统计学意义。HIV组不同免疫抑制阶段对治疗的反应无统计学显著差异。该组的免疫状态也没有恶化。UVB光疗对感染HIV的银屑病患者是一种有效的治疗方法。其反应与配对对照个体相同。
