Hjelle J T, Miller-Hjelle M A, Dobbie J W
University of Illinois College of Medicine at Peoria 61729, USA.
Perit Dial Int. 1995;15(7 Suppl):S13-22; discussion S22-3.
Substantial derangements of mesothelial biology are observed during experimental simulations of dialysis conditions, inferred from the content of human dialysis effluent and visualized by microscopy of human mesothelial biopsies. Can osmotically active solutions be made biocompatible with the osmoregulatory system of the mesothelium? Can the contributions of the mesothelium to host defenses against inflammation and/or infection be supported during CAPD? Do underlying metabolic derangements present in various kidney diseases and end-stage renal disease, regardless of cause, require customized CAPD protocols and solutions? Use of dialysis solutions less directly toxic to the mesothelium is a necessary step toward some day manipulating peritoneal biology by pharmacological and therapeutic modalities.
在透析条件的实验模拟过程中观察到间皮生物学的显著紊乱，这是根据人透析流出液的成分推断出来的，并通过人腹膜间皮活检的显微镜检查得以显现。具有渗透活性的溶液能否与间皮的渗透调节系统实现生物相容性？在持续性非卧床腹膜透析（CAPD）期间，间皮对宿主抵御炎症和/或感染的贡献能否得到支持？无论病因如何，各种肾脏疾病和终末期肾病中存在的潜在代谢紊乱是否需要定制的CAPD方案和溶液？使用对间皮毒性较小的透析液是朝着有朝一日通过药理学和治疗方法操控腹膜生物学迈出的必要一步。
