Kalayam B, Meyers B S, Kakuma T, Alexopoulos G S, Young R C, Solomon S, Shotland R, Nambudiri D, Goldsmith D
Department of Psychiatry, Cornell University Medical College, New York, NY.
Biol Psychiatry. 1995 Nov 15;38(10):649-58. doi: 10.1016/0006-3223(95)00175-1.
Comorbidity of sensorineural hearing deficits and both depressive states and dementia in late life provided the rationale for this investigation. Cognitively intact geriatric major depressives (n = 43) were assessed for depressive symptoms, cognitive performance, and delusions while symptomatic, and following treatment, when audiometry was performed. Late-onset depressed patients (LOD) had more hearing deficits compared to early-onset depressives (EOD). Age at onset of depression was found to have a significant effect on Pure-Tone Thresholds for 0.5-4.0 kHz and on Word Recognition in Noise in the better ear (0.001 < p < 0.031; ANCOVA). Criteria for neural deficit were met more frequently in LODs compared to EODs, although this was attributable to the older age of LOD. Additional investigations can contribute to our understanding of the relationship between forms of hearing loss and both the course of geriatric depression and its relationship to dementia.
感音神经性听力缺陷与晚年抑郁状态和痴呆症的共病现象为本次调查提供了依据。对认知功能正常的老年重度抑郁症患者（n = 43）在出现症状时、治疗期间以及进行听力测试时，评估其抑郁症状、认知表现和妄想情况。晚发性抑郁症患者（LOD）与早发性抑郁症患者（EOD）相比，听力缺陷更多。发现抑郁症发病年龄对0.5 - 4.0 kHz的纯音阈值以及较好耳的噪声中的单词识别有显著影响（0.001 < p < 0.031；协方差分析）。与EOD相比，LOD更频繁地符合神经缺陷标准，尽管这归因于LOD患者年龄较大。进一步的研究有助于我们理解听力损失形式与老年抑郁症病程及其与痴呆症关系之间的联系。
