Cornélissen G, Halberg F, Walker R, Zaslavskaya R M, Fine R L, Haus E
University of Minnesota, Minneapolis 55455, USA.
In Vivo. 1995 Jul-Aug;9(4):359-62.
When using urinary gonadotropin peptide (UGP) as a marker for ovarian cancer, a circadian rhythm of large amplitude is best assessed for improving preanalytic quality control, for specifying how often and when to sample and for resolving chronobiologic endpoints. In a patient (EH, 73 y) with an ovarian (Müllerian) adenocarcinoma, overall high UGP values occurred consistently around 07:00 (standard deviation, SD = 2 h), similar to the timing observed in a presumably healthy woman. The circadian rhythm of EH averages in amplitude about 45% of the daily mean value (SD = 15%). The results indicate the desirability of deriving time-specified reference limits in health for an improved diagnostic value of UGP. The circadian UGP pattern awaits tests of applications for a chronodiagnosis of ovarian cancer, for optimizing treatment efficacy by timing according to rhythms, and conceivably for detecting earliest precancer risk.
将尿促性腺激素肽（UGP）用作卵巢癌标志物时，最好评估大幅度的昼夜节律，以改善分析前质量控制、确定采样频率和时间，并解决时间生物学终点问题。在一名患有卵巢（苗勒氏）腺癌的患者（EH，73岁）中，UGP总体高值始终出现在07:00左右（标准差，SD = 2小时），这与在一名可能健康的女性中观察到的时间相似。EH的昼夜节律幅度平均约为每日平均值的45%（SD = 15%）。结果表明，为提高UGP的诊断价值，需要得出健康状态下按时间指定的参考限值。昼夜UGP模式有待于在卵巢癌的时间诊断、根据节律安排时间以优化治疗效果以及可能检测最早的癌前风险方面进行应用测试。
