Lonergan J M, Orlowski J P, Sato T, McHugh M J, Zborowski M
Department of Pediatrics, Cleveland Clinic Foundation, OH, USA.
ASAIO J. 1994 Jul-Sep;40(3):M654-7. doi: 10.1097/00002480-199407000-00079.
The authors induced endotoxic shock in an animal model and attempted to treat this state by direct hemoperfusion over a modified anion sorbent column. It has been shown that the reversal of septic shock correlates with the efficiency of extracorporeal endotoxin removal. In this experiment, there were five control animals (sham) and five test animals (hemoperfusion over sorbent column). The efficacy of treatment was evaluated by survival at 24 hr, changes in mean arterial pressure, blood-acid base balance, and plasma endotoxin levels. There was 0% survival in the control group and 100% survival in the test group. The control dogs never recovered from shock or metabolic acidosis, but the test animals were at their initial values for these parameters by 6 hr. The endotoxin levels measured at 6 hr were higher in the control group (265 +/- 88 ng/ml) as compared with the test group (7.0 +/- 6.2 ng/ml). Direct hemoperfusion over a modified sorbent column effectively removed endotoxin and reversed the course of fatal septic shock.
作者在动物模型中诱导内毒素休克，并尝试通过在改良的阴离子吸附柱上进行直接血液灌流来治疗这种状态。已表明脓毒性休克的逆转与体外内毒素清除效率相关。在该实验中，有五只对照动物（假手术组）和五只试验动物（在吸附柱上进行血液灌流）。通过24小时存活率、平均动脉压变化、血液酸碱平衡和血浆内毒素水平来评估治疗效果。对照组存活率为0%，试验组存活率为100%。对照犬从未从休克或代谢性酸中毒中恢复，但试验动物在6小时时这些参数恢复到初始值。对照组在6小时时测得的内毒素水平（265±88 ng/ml）高于试验组（7.0±6.2 ng/ml）。在改良的吸附柱上进行直接血液灌流可有效清除内毒素并逆转致命性脓毒性休克的病程。
