Löw O, Strecke J, Oettel M
Exp Pathol (Jena). 1979;17(1):53-62.
In growth inhibiting tests of rat testes the tubular diameter and, somewhat less sensitive, the nuclear volume of the Leydig cell follow the weight changes. Chlormadinone acetate shows antigonadotropic activity only at high doses and a dose-dependent antiandrogenic activity. The dose-weight curve under norethisterone acetate has a minimum at 4.2 mg/rat/14 days; higher doses seem to be accompanied by androgenic efficiency.
在大鼠睾丸生长抑制试验中，曲细精管直径以及对莱迪希细胞（间质细胞）核体积变化不太敏感的指标，均随体重变化而改变。醋酸氯地孕酮仅在高剂量时显示抗促性腺活性，且具有剂量依赖性抗雄激素活性。醋酸炔诺酮的剂量 - 体重曲线在4.2毫克/大鼠/14天时有一个最低点；更高剂量似乎伴随着雄激素效应。
