Sosa-Melgarejo J A, Berry C L
Departamento de Anatomía Patológica, Hospital de Cardiología, Instituto Mexicano del Seguro Social, México, D.F.
Arch Med Res. 1995 Winter;26(4):431-5.
Intracellular communication is an essential process in both embryological development and for the maintenance of normal tissue physiology. We have established the presence of this type of communication between endothelial cells and vascular smooth muscle cells in man and have here investigated the close contacts between endothelial and smooth muscle cells in the aorta of the 10-week-old human fetus. Transmission electron microscopy revealed myoendothelial contacts in the form of cytoplasmic projections, usually originating from the muscle cells. The nature of the cell-cell contacts was via simple appositions with an intercellular space of 6-15 nm. Myoendothelial contacts are sites for communication between elements of the intima and media, ensuring that paracrine secretion can occur and that the vessel wall, during growth and development, works as a unit.
细胞内通讯在胚胎发育以及维持正常组织生理过程中都是一个必不可少的过程。我们已经证实了人类内皮细胞与血管平滑肌细胞之间存在这种通讯方式，并且在此研究了10周龄人类胎儿主动脉中内皮细胞与平滑肌细胞之间的紧密接触。透射电子显微镜显示，肌内皮接触呈细胞质突起的形式，通常起源于肌肉细胞。细胞间接触的本质是通过简单并列，细胞间隙为6 - 15纳米。肌内皮接触是内膜和中膜成分之间通讯的位点，确保旁分泌分泌能够发生，并且在生长和发育过程中血管壁作为一个整体发挥作用。
