Kolpakov V A, Rekhter M D, Peretiatko L P, Kulida L V, Mironov A A
Morfologiia. 1993 Mar-Apr;104(3-4):80-7.
Transmission electron microscopy was used for studying the thoracic part of the aorta of 9 human fetuses of 20-28 weeks of development. In the medial tunic of the human fetus aorta there are smooth myocytes (SM) of the contractile and synthetic phenotypes. The latter are localized mainly in the inner part of the media. In the inner tunic there are also SM of the synthetic phenotype. With the help of processes they make contacts with endotheliocytes and processes of SM of the media. In the gaps between the subendothelial SM and endothelium there are particles of elastin which form the structure resembling an additional elastic membrane. It is reasonable to think that the migration of SM into the intima is a stage of normal development of the vessel associated with the adaptation to local hemodynamic conditions rather than an initial manifestation of atherosclerosis.
采用透射电子显微镜研究了9例发育20 - 28周的人类胎儿主动脉胸部。在人类胎儿主动脉的中膜层存在收缩型和合成型表型的平滑肌细胞（SM）。后者主要位于中膜的内部。在内膜层也有合成型表型的SM。它们通过突起与内皮细胞和中膜SM的突起建立联系。在内皮下SM与内皮之间的间隙中有弹性蛋白颗粒，其形成类似于额外弹性膜的结构。有理由认为，SM向内膜的迁移是血管正常发育的一个阶段，与适应局部血流动力学条件有关，而不是动脉粥样硬化的初始表现。
