Famodu A A, Oduwa D
Department of Haematology, Faculty of Medicine, University of Benin, Nigeria.
Br J Biomed Sci. 1995 Dec;52(4):323-4.
In view of the effect of red blood cell membrane on platelet factor 3 release in sickle cell disease, platelet count and platelet factor 3 (PF-3) availability were measured in 30 sickle cell patients in a stable state and 15 with thrombocytosis, and these were compared with 60 non-sickle cell individuals as controls. There were no significant differences in platelet counts, but there was a slightly higher PF-3 availability in sickle cell patients not in crisis than in the controls (P < 0.025). Sickle cell patients with thrombocytosis made PF-3 available more readily than did the control individuals and sickle cell patients not in crisis (P < 0.001). We conclude that sickle cell patients are capable of making platelet factor 3 readily available for coagulation activation, and this may play a decisive role in vaso-occlusive crisis.
鉴于红细胞膜对镰状细胞病中血小板因子3释放的影响，我们对30例病情稳定的镰状细胞病患者和15例血小板增多症患者进行了血小板计数和血小板因子3（PF-3）可用性的检测，并将其与60例非镰状细胞病个体作为对照进行比较。血小板计数无显著差异，但非危象期镰状细胞病患者的PF-3可用性略高于对照组（P < 0.025）。血小板增多症的镰状细胞病患者比对照组和非危象期镰状细胞病患者更容易释放PF-3（P < 0.001）。我们得出结论，镰状细胞病患者能够使血小板因子3易于用于凝血激活，这可能在血管阻塞性危象中起决定性作用。
