Kawada T, Yamanaka H, Hasegawa Y
Department of Urology, Gunma University School of Medicine, Maebashi, Japan.
Endocr J. 1995 Aug;42(4):577-80. doi: 10.1507/endocrj.42.577.
The blood FSH level is often high in patients with severe testicular disorders including cryptorchids. To examine whether inhibin is involved in the increase in FSH we measured immunoreactive inhibin, FSH, LH, and testosterone in 17 patients after orchidopexy. FSH was extremely high (20 mIU/ml or above) in 3 patients. The inhibin level was significantly lower (P < 0.01) in these 3 patients (6.47 +/- 2.19 IU/ml; mean +/- SEM) than in the other 14 patients (14.31 +/- 3.96 IU/ml). All 3 high-FSH patients had azoospermia. Testosterone and LH were normal in one of them. Even considering problems involved in the inhibin assay, the high FSH levels are considered to reflect reductions in the blood inhibin level due to Sertoli cell dysfunction. These findings suggest that inhibin plays an important role in the suppression of FSH at least in some patients after orchidopexy.
包括隐睾症在内的严重睾丸疾病患者的血液促卵泡激素（FSH）水平通常较高。为了研究抑制素是否与FSH升高有关，我们对17例睾丸固定术后的患者测定了免疫反应性抑制素、FSH、促黄体生成素（LH）和睾酮。3例患者的FSH极高（20 mIU/ml及以上）。这3例患者的抑制素水平（6.47±2.19 IU/ml；平均值±标准误）显著低于其他14例患者（14.31±3.96 IU/ml，P<0.01）。所有3例FSH水平高的患者均无精子症。其中1例患者的睾酮和LH正常。即使考虑到抑制素检测中存在的问题，高FSH水平仍被认为反映了由于支持细胞功能障碍导致的血液抑制素水平降低。这些发现表明，抑制素至少在部分睾丸固定术后患者中对FSH的抑制起重要作用。
