Mahmoud A M, Comhaire F H, Vereecken A, Verhoeven G, Abdel-Rahim D E, Abdel-Hafez K M
Department of Dermatology and Andrology, Assiut University Hospitals, Egypt.
Andrologia. 1996 Mar-Apr;28(2):103-8. doi: 10.1111/j.1439-0272.1996.tb02764.x.
Static measurements of immunoreactive inhibin have proven of little relevance in the diagnosis of testicular disorders. Dynamic evaluation of the inhibin secretory reserve might detect a specific Sertoli cell defect in a subgroup of infertile men. We compared the response of inhibin and steroids to an intravenous injection of pure FSH (Metrodin, Serono, 300 IU) in 13 infertile men with unilateral cryptorchidism to that in eight normal fertile men. Blood was aspirated before, 24, 48, and 72 h after the FSH injection. Two subgroups of patients with unilateral cryptorchidism were detected: those who responded by secreting inhibin in a pattern similar to normal men (seven patients), and those who responded poorly or not at all (six patients). The presumed cause of this difference is a defect of Sertoli cell reserve function due to a combination of insults to the testes, and not to cryptorchidism itself. The difference in response to FSH cannot be predicted from semen analysis nor from static hormone measurements. Overall, inhibin levels correlated significantly with the serum concentrations of FSH (r = -0.36, P < 0.05), testosterone (r = 0.37, P < 0.05), and 17-hydroxyprogesterone (r = 0.66, P < 0.001). It is concluded that, in infertile men with unilateral cryptorchidism, Stimulation of Sertoli cells by FSH can identify a subgroup of patients with Sertoli cell malfunction involving inhibin synthesis.
免疫反应性抑制素的静态测量已证明对睾丸疾病的诊断意义不大。对抑制素分泌储备的动态评估可能会在一部分不育男性中检测到特定的支持细胞缺陷。我们比较了13名单侧隐睾不育男性与8名正常生育男性在静脉注射纯促卵泡激素（Metrodin，雪兰诺公司，300国际单位）后抑制素和类固醇的反应。在促卵泡激素注射前、注射后24、48和72小时采集血液。检测到单侧隐睾患者的两个亚组：那些以与正常男性相似的模式分泌抑制素做出反应的患者（7例），以及那些反应不佳或根本无反应的患者（6例）。这种差异的推测原因是由于对睾丸的多种损伤导致支持细胞储备功能缺陷，而非隐睾本身。从精液分析或静态激素测量无法预测对促卵泡激素反应的差异。总体而言，抑制素水平与促卵泡激素的血清浓度（r = -0.36，P < 0.05）、睾酮（r = 0.37，P < 0.05）和17 - 羟孕酮（r = 0.66，P < 0.001）显著相关。结论是，在单侧隐睾不育男性中，促卵泡激素对支持细胞的刺激可识别出涉及抑制素合成的支持细胞功能障碍患者亚组。
