Di Pasquale E, Monteau R, Hilaire G, Iscoe S
Laboratoire de Biologie des Rythmes et du Développement, URA, CNRS 1832, Faculté des Sciences et Techniques St.-Jérôme, Marseille, France.
Brain Res. 1995 Oct 16;695(2):271-4. doi: 10.1016/0006-8993(95)00903-4.
Ethanol (1-12 mM) added to the superfusion medium of the isolated brainstem-spinal cords of newborn rats did not affect phrenic activity but significantly reduced hypoglossal activity by 54%, 67% and 55% at 3, 6 and 12 mM, respectively. Although the reasons for the suppression of hypoglossal activity remain unknown, this preparation may be a useful model for determining why cranial motoneurons are more vulnerable than phrenic motoneurons to various agents and, more generally, how ethanol impairs neural function.
向新生大鼠离体脑干脊髓的灌流介质中添加乙醇（1 - 12 mM），对膈神经活动没有影响，但在3 mM、6 mM和12 mM时，分别使舌下神经活动显著降低了54%、67%和55%。尽管舌下神经活动受抑制的原因尚不清楚，但该制备模型可能有助于确定为何颅运动神经元比膈运动神经元更容易受到各种因素的影响，更普遍地说，有助于确定乙醇如何损害神经功能。
