de Oliveira Cordeiro J G
Department of Preventive Dentistry and Public Health, Faculty of Dentistry, Tokyo Medical and Dental University.
Bull Tokyo Med Dent Univ. 1995 Dec;42(3):83-103.
The aim of this study was to investigate the development of root surface caries in hamsters fed a high-sucrose diet over a 24-week period after inoculations of two types of cariogenic bacteria. Twenty-one day old male golden hamsters (n = 103) were divided into 5 groups. Four groups were given diet 2000, and one group was given a stock diet CE-2, Of the groups given diet 2000, three groups were infected with Actinomyces viscosus ATCC 15987 and Streptococcus mutans NTCC 10449 separately (AV and SM groups) or in combination (AVSM group), and one group remained uninfected. A grid method was used to evaluate the plaque accumulation, alveolar bone loss, and root surface caries. After 12 weeks, root surface caries developed mainly on the first mandibular molars in the three infected groups. At 24 weeks, the prevalence of root surface caries was highest in the AV group, but root caries scores were not significantly different among the three infected groups. In the groups SM and AVSM, the molar crowns were extensively destroyed by caries, while in the AV group the crowns were almost intact. It was concluded that challenge with Actinomyces viscosus may be appropriate to study root surface caries in hamsters.
本研究的目的是调查在接种两种致龋菌后，喂食高蔗糖饮食24周的仓鼠根面龋的发展情况。将21日龄雄性金黄仓鼠（n = 103）分为5组。4组给予2000号饮食，1组给予基础饮食CE - 2。在给予2000号饮食的组中，3组分别单独感染粘性放线菌ATCC 15987和变形链球菌NTCC 10449（AV组和SM组）或联合感染（AVSM组），1组未感染。采用网格法评估菌斑积聚、牙槽骨丧失和根面龋情况。12周后，根面龋主要发生在3个感染组的第一下颌磨牙上。24周时，AV组根面龋患病率最高，但3个感染组的根龋评分无显著差异。在SM组和AVSM组中，磨牙牙冠被龋病广泛破坏，而在AV组中牙冠几乎完好无损。得出的结论是，用粘性放线菌进行攻毒可能适合于研究仓鼠的根面龋。
