Shi G, Xu Z, Fu C, Weng X
Division of Clinical Science, Huashan Hospital, Shanghai Medical University.
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 1995;13(3):189-92.
Employing Capture ELISA, we determined the level of the circulating soluble egg antigen-antibody complex (SEAIC) in sera from mice infected with Schistosoma japonicum for 7 weeks and then treated the infected mice with praziquantel (100 mg/kg body weight). It was noted that the serum SEAIC level in treated mice dropped gradually after treatment. There was a significant decrease in 13 out of 15 mice in serum SEAIC levels at five weeks after treatment, OD value dropped from 0.358 +/- 0.074 to 0.165 +/- 0.049 (P < 0.01). The serum SEAIC level in 10 mice declined to disappear (OD < 0.097) by the 7th week after treatment. By contrast, no significant changes in serum SEAIC levels were found in the non-treated mice, the serum SEAIC level in the control group maintained moderately high (OD = 0.266 +/- 0.076) till the end of the observation.
采用捕获ELISA法，我们测定了感染日本血吸虫7周的小鼠血清中循环可溶性虫卵抗原-抗体复合物（SEAIC）的水平，然后用吡喹酮（100mg/kg体重）治疗感染小鼠。结果发现，治疗后小鼠血清SEAIC水平逐渐下降。治疗后5周，15只小鼠中有13只血清SEAIC水平显著下降，OD值从0.358±0.074降至0.165±0.049（P<0.01）。治疗后第7周，10只小鼠的血清SEAIC水平下降至消失（OD<0.097）。相比之下，未治疗小鼠的血清SEAIC水平无显著变化，对照组血清SEAIC水平在观察结束时一直维持在中等高度（OD = 0.266±0.076）。
