Zhang Y, Lei J, Zhang M, Wan X, Li C
Department of Parasitology, Xi an Medical University.
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 1995;13(3):222-4.
The dynamics of circulating antigen (CAg) level in sera form patients with cysticercosis before and after albendazole treatment were detected by using monoclonal antibody-based double antibody sandwich ELISA (McAb-ELISA). The results indicate that after the patients with cysticercosis had been treated for one, two and three treatment courses, the levels of CAg in sera decreased with the increase in the number of treatment courses, their average OD value dropped from 0.499 before treatment to 0.291, 0.073 and 0.051 after treatment, respectively, and the corresponding negative conversion rates of CAg detection were 20.0%, 57.9% and 87.5%, respectively. Sera from eight patients who had received three courses of albendazole treatment were detected for CAg and CAb before and after treatment. The results indicate that the CAb level dropped rather slowly after three courses of treatment as compared to CAg level. It is concluded that detecting circulating antigen might be used as a promising method for evaluating the drug efficacy.
采用基于单克隆抗体的双抗体夹心ELISA（McAb-ELISA）检测了囊尾蚴病患者阿苯达唑治疗前后血清中循环抗原（CAg）水平的动态变化。结果表明，囊尾蚴病患者经1个、2个和3个疗程治疗后，血清中CAg水平随疗程数增加而降低，其平均OD值分别从治疗前的0.499降至治疗后的0.291、0.073和0.051，相应的CAg检测转阴率分别为20.0%、57.9%和87.5%。对8例接受3个疗程阿苯达唑治疗的患者治疗前后的血清进行CAg和循环抗体（CAb）检测。结果表明，与CAg水平相比，3个疗程治疗后CAb水平下降较慢。结论是，检测循环抗原可能是一种有前景的评价药物疗效的方法。
