Heng C K, Saha N, Tay J S
Department of Paediatrics, National University of Singapore, Republic of Singapore.
Clin Genet. 1995 Sep;48(3):113-9. doi: 10.1111/j.1399-0004.1995.tb04068.x.
Apolipoprotein E (apoE) polymorphism and its influence on plasma lipids, lipoproteins, lipoprotein (a) [Lp(a)] and apolipoproteins was studied in 536 (270 males and 266 females) healthy Chinese in Singapore. From analysis of variance with age and BMI as covariates, apoE genotype was found to exert a significant influence on plasma total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and apoB in females. Its effect in males was marginally significant only on LDL-C. In both sexes, plasma TC, LDL-C and apoB were lower in those who were E2-3 than in those who were E3-3. There was no significant difference in log-transformed Lp(a) level between the apoE genotypes after adjusting for the confounding effect of LDL-C in addition to age and BMI. The percentage variance (R2 x 100) of the lipid traits explained by apoE polymorphism in the females was 4.94% for plasma TC, 5.85% for LDL-C and 4.25% for apoB. We conclude that: 1) epsilon 2 allele had a lowering effect on plasma TC, LDL-C and apoB; 2) apoE polymorphism did not have any significant influence on Lp(a) concentration; and 3) the effect of apoE polymorphism on plasma TC, LDL-C and apoB was gender-specific, with a stronger influence in females than in males.
在新加坡的536名（270名男性和266名女性）健康中国人中，研究了载脂蛋白E（apoE）多态性及其对血浆脂质、脂蛋白、脂蛋白(a) [Lp(a)]和载脂蛋白的影响。通过以年龄和体重指数作为协变量的方差分析发现，apoE基因型对女性的血浆总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）和载脂蛋白B有显著影响。其对男性的影响仅对LDL-C有微弱的显著性。在两性中，E2-3基因型者的血浆TC、LDL-C和载脂蛋白B均低于E3-3基因型者。在调整了LDL-C以及年龄和体重指数的混杂效应后，apoE基因型之间的对数转换Lp(a)水平没有显著差异。apoE多态性在女性中对血浆脂质特征的百分比变异率（R2×100），血浆TC为4.94%，LDL-C为5.85%，载脂蛋白B为4.25%。我们得出结论：1）ε2等位基因对血浆TC、LDL-C和载脂蛋白B有降低作用；2）apoE多态性对Lp(a)浓度没有任何显著影响；3）apoE多态性对血浆TC、LDL-C和载脂蛋白B的影响具有性别特异性，对女性的影响强于男性。
