Hofmockel R, Benad G
Clinic of Anaesthesiology and Intensive Therapy, School of Medicine, University of Rostock, Germany.
Eur J Anaesthesiol Suppl. 1995 Sep;11:69-72.
Thirty ASA I and II patients received either an intubating dose of 0.6 mg kg-1 rocuronium (2 x ED95, group 1) or 0.06 mg kg-1 as a priming dose followed by an intubating dose of 0.24 mg kg-1 rocuronium (group 2) 4 min later. Anaesthesia was induced with propofol (2.0 mg kg-1) and alfentanil (0.02 mg kg-1) and maintained with nitrous oxide/oxygen and propofol (6.0 mg kg-1 h-1). Neuromuscular function was monitored mechanomyographically and electromyographically with train-of-four (TOF) stimulation at the wrist every 10 s. The following parameters were measured and compared between the two groups: time to 90% block (intubation time), time to maximum block (onset time), and the times for T1 (25%, 75% and 90%) and TOF > 70%. In group 1 the intubation time was significantly shorter (40 +/- 10 s) than in group 2 (51 +/- 11 s). Intubating conditions were good or excellent in both groups. The clinical duration of action was 28 +/- 8 min in group 1 and 15 +/- 3 min in group 2, respectively. Mechanomyography showed a significantly faster development of neuromuscular block than electromyography. The comparison of mechanomyographically and electromyographically measured recovery times did not show any differences. In 60% of the patients a priming dose of 0.06 mg kg-1 was followed by a considerable decrease in neuromuscular function.
30例美国麻醉医师协会（ASA）分级为I级和II级的患者，分别接受0.6 mg·kg-1罗库溴铵的插管剂量（2倍ED95，第1组）或0.06 mg·kg-1的预充剂量，4分钟后再接受0.24 mg·kg-1罗库溴铵的插管剂量（第2组）。采用丙泊酚（2.0 mg·kg-1）和阿芬太尼（0.02 mg·kg-1）诱导麻醉，并用氧化亚氮/氧气和丙泊酚（6.0 mg·kg-1·h-1）维持麻醉。每隔10秒在腕部用四个成串刺激（TOF）通过肌机械图和肌电图监测神经肌肉功能。测量并比较两组的以下参数：达到90%阻滞的时间（插管时间）、达到最大阻滞的时间（起效时间）以及T1（25%、75%和90%）和TOF>70%的时间。第1组的插管时间（40±10秒）明显短于第2组（51±11秒）。两组的插管条件均为良好或极佳。第1组和第2组的临床作用持续时间分别为28±8分钟和15±3分钟。肌机械图显示神经肌肉阻滞的发展明显快于肌电图。肌机械图和肌电图测量的恢复时间比较未显示任何差异。60%的患者接受0.06 mg·kg-1的预充剂量后，神经肌肉功能显著下降。
