用产志贺样毒素I B亚单位的霍乱弧菌CVD 103-HgR口服免疫后对志贺样毒素I的保护性免疫。
Protective immunity to Shiga-like toxin I following oral immunization with Shiga-like toxin I B-subunit-producing Vibrio cholerae CVD 103-HgR.
作者信息
Acheson D W, Levine M M, Kaper J B, Keusch G T
机构信息
Division of Geographic Medicine and Infectious Diseases, New England Medical Center, Boston, Massachusetts 02111, USA.
出版信息
Infect Immun. 1996 Jan;64(1):355-7. doi: 10.1128/iai.64.1.355-357.1996.
Abstract
This study addresses a mechanism for inducing systemic immunity to Shiga-like toxins by oral administration of a Shiga-like toxin I B-subunit-expressing Vibrio cholerae vaccine strain [CVD 103-HgR(pDA60)]. Two sets of three rabbits were given either CVD 103-HgR or CVD 103-HgR(pDA60) orally. All rabbits immunized with CVD 103-HgR(pDA60) developed neutralizing serum antibodies to Shiga-like toxin I. None of the controls developed such antibodies.
摘要
本研究探讨了通过口服表达志贺样毒素I B亚基的霍乱弧菌疫苗株[CVD 103-HgR(pDA60)]诱导针对志贺样毒素的全身免疫的机制。将两组各三只兔子分别口服给予CVD 103-HgR或CVD 103-HgR(pDA60)。所有用CVD 103-HgR(pDA60)免疫的兔子都产生了针对志贺样毒素I的中和血清抗体。对照组兔子均未产生此类抗体。
相似文献
1
Protective immunity to Shiga-like toxin I following oral immunization with Shiga-like toxin I B-subunit-producing Vibrio cholerae CVD 103-HgR.用产志贺样毒素I B亚单位的霍乱弧菌CVD 103-HgR口服免疫后对志贺样毒素I的保护性免疫。
Infect Immun. 1996 Jan;64(1):355-7. doi: 10.1128/iai.64.1.355-357.1996.
2
A review of the current status of enteric vaccines.肠道疫苗现状综述
P N G Med J. 1995 Dec;38(4):325-31.
3
Randomized, double-blind, placebo-controlled, multicentered trial of the efficacy of a single dose of live oral cholera vaccine CVD 103-HgR in preventing cholera following challenge with Vibrio cholerae O1 El tor inaba three months after vaccination.单剂量口服霍乱活疫苗CVD 103-HgR接种三个月后，用霍乱弧菌O1 El tor稻叶型毒株攻击，预防霍乱效果的随机、双盲、安慰剂对照、多中心试验。
Infect Immun. 1999 Dec;67(12):6341-5. doi: 10.1128/IAI.67.12.6341-6345.1999.
4
Protection against Shiga toxin-producing Escherichia coli infection by transcutaneous immunization with Shiga toxin subunit B.通过用志贺毒素B亚基经皮免疫来预防产志贺毒素大肠杆菌感染
Clin Vaccine Immunol. 2008 Feb;15(2):359-66. doi: 10.1128/CVI.00399-07. Epub 2007 Nov 14.
5
Intranasal immunization with recombinant toxin-coregulated pilus and cholera toxin B subunit protects rabbits against Vibrio cholerae O1 challenge.用重组毒素调节菌毛和霍乱毒素B亚单位进行鼻内免疫可保护兔子免受霍乱弧菌O1的攻击。
FEMS Immunol Med Microbiol. 2009 Jul;56(2):179-84. doi: 10.1111/j.1574-695X.2009.00563.x. Epub 2009 May 5.
6
Coexpression of the B subunit of Shiga toxin 1 and EaeA from enterohemorrhagic Escherichia coli in Vibrio cholerae vaccine strains.霍乱弧菌疫苗菌株中志贺毒素1 B亚基与肠出血性大肠杆菌EaeA的共表达。
Infect Immun. 1997 Jun;65(6):2127-35. doi: 10.1128/iai.65.6.2127-2135.1997.
7
Analysis of efficacy of CVD 103-HgR live oral cholera vaccine against all-cause travellers' diarrhoea in a randomised, double-blind, placebo-controlled study.在一项随机、双盲、安慰剂对照研究中，分析CVD 103-HgR口服霍乱活疫苗对预防旅行者全因性腹泻的疗效。
Vaccine. 2005 Oct 17;23(43):5120-6. doi: 10.1016/j.vaccine.2005.05.022.
8
Onset and duration of protective immunity in challenged volunteers after vaccination with live oral cholera vaccine CVD 103-HgR.口服霍乱活疫苗CVD 103-HgR接种后，受挑战志愿者体内保护性免疫的起始和持续时间。
J Infect Dis. 1992 Oct;166(4):837-41. doi: 10.1093/infdis/166.4.837.
9
Heterologous antigen expression in Vibrio cholerae vector strains.霍乱弧菌载体菌株中的异源抗原表达。
Infect Immun. 1995 Jul;63(7):2689-96. doi: 10.1128/iai.63.7.2689-2696.1995.
10
Safety, immunogenicity, and efficacy of recombinant live oral cholera vaccines, CVD 103 and CVD 103-HgR.重组活口服霍乱疫苗CVD 103和CVD 103-HgR的安全性、免疫原性及有效性
Lancet. 1988 Aug 27;2(8609):467-70. doi: 10.1016/s0140-6736(88)90120-1.
引用本文的文献
1
Treatment Strategies for Infections With Shiga Toxin-Producing .产志贺毒素大肠埃希氏菌感染的治疗策略。
Front Cell Infect Microbiol. 2020 May 6;10:169. doi: 10.3389/fcimb.2020.00169. eCollection 2020.
2
Protection by a recombinant Mycobacterium bovis Bacillus Calmette-Guerin vaccine expressing Shiga toxin 2 B subunit against Shiga toxin-producing Escherichia coli in mice.表达志贺毒素2 B亚基的重组牛分枝杆菌卡介苗对小鼠产志贺毒素大肠杆菌的保护作用。
Clin Vaccine Immunol. 2012 Dec;19(12):1932-7. doi: 10.1128/CVI.00473-12. Epub 2012 Oct 3.
3
Live attenuated Shigella dysenteriae type 1 vaccine strains overexpressing shiga toxin B subunit.表达志贺毒素 B 亚单位的减毒活痢疾志贺菌 1 型疫苗株。
Infect Immun. 2011 Dec;79(12):4912-22. doi: 10.1128/IAI.05814-11. Epub 2011 Oct 3.
4
Protection against Escherichia coli O157:H7 challenge by immunization of mice with purified Tir proteins.用纯化的 Tir 蛋白免疫小鼠预防大肠杆菌 O157:H7 感染。
Mol Biol Rep. 2012 Feb;39(2):989-97. doi: 10.1007/s11033-011-0824-0. Epub 2011 May 13.
5
Salmonella enterica serovar Typhimurium vaccine strains expressing a nontoxic Shiga-like toxin 2 derivative induce partial protective immunity to the toxin expressed by enterohemorrhagic Escherichia coli.表达无毒志贺样毒素2衍生物的肠炎沙门氏菌鼠伤寒血清型疫苗株可诱导对肠出血性大肠杆菌表达的毒素产生部分保护性免疫。
Clin Vaccine Immunol. 2010 Apr;17(4):529-36. doi: 10.1128/CVI.00495-09. Epub 2010 Feb 10.
6
Development of a live oral attaching and effacing Escherichia coli vaccine candidate using Vibrio cholerae CVD 103-HgR as antigen vector.利用霍乱弧菌 CVD103-HgR 作为抗原载体开发活口服黏附侵袭性大肠杆菌疫苗候选物。
Microb Pathog. 2010 Jan;48(1):1-8. doi: 10.1016/j.micpath.2009.10.005. Epub 2009 Oct 28.
7
A DNA vaccine encoding the enterohemorragic Escherichia coli Shiga-like toxin 2 A2 and B subunits confers protective immunity to Shiga toxin challenge in the murine model.一种编码肠出血性大肠杆菌志贺样毒素2 A2和B亚基的DNA疫苗在小鼠模型中对志贺毒素攻击具有保护性免疫作用。
Clin Vaccine Immunol. 2009 May;16(5):712-8. doi: 10.1128/CVI.00328-08. Epub 2009 Jan 28.
8
Recombinant Shiga toxin B-subunit-keyhole limpet hemocyanin conjugate vaccine protects mice from Shigatoxemia.重组志贺毒素B亚基-钥孔血蓝蛋白结合疫苗可保护小鼠免受志贺毒素血症的侵害。
Infect Immun. 2005 Oct;73(10):6523-9. doi: 10.1128/IAI.73.10.6523-6529.2005.
9
Construction and evaluation of a safe, live, oral Vibrio cholerae vaccine candidate, IEM108.安全、活口服霍乱弧菌候选疫苗IEM108的构建与评价
Infect Immun. 2003 Oct;71(10):5498-504. doi: 10.1128/IAI.71.10.5498-5504.2003.
10
Protection against Shiga toxin 1 challenge by immunization of mice with purified mutant Shiga toxin 1.用纯化的突变型志贺毒素1免疫小鼠对志贺毒素1攻击的保护作用。
Infect Immun. 2003 Jun;71(6):3235-9. doi: 10.1128/IAI.71.6.3235-3239.2003.
本文引用的文献
1
Comparison of Shiga-like toxin I B-subunit expression and localization in Escherichia coli and Vibrio cholerae by using trc or iron-regulated promoter systems.利用trc或铁调节启动子系统比较大肠杆菌和霍乱弧菌中志贺样毒素I B亚基的表达与定位
Infect Immun. 1993 Mar;61(3):1098-104. doi: 10.1128/iai.61.3.1098-1104.1993.
2
Southwestern Internal Medicine Conference: Shiga-like toxins in hemolytic-uremic syndrome and thrombotic thrombocytopenic purpura.西南内科医学会议：溶血尿毒综合征和血栓性血小板减少性紫癜中的志贺样毒素
Am J Med Sci. 1993 Dec;306(6):398-406. doi: 10.1097/00000441-199312000-00009.
3
Expression and purification of Shiga-like toxin II B subunits.志贺样毒素II B亚单位的表达与纯化
Infect Immun. 1995 Jan;63(1):301-8. doi: 10.1128/iai.63.1.301-308.1995.
4
Quantitative microtiter cytotoxicity assay for Shigella toxin.志贺毒素的定量微量滴定细胞毒性测定
J Clin Microbiol. 1980 Sep;12(3):361-6. doi: 10.1128/jcm.12.3.361-366.1980.
5
The pathogenesis of Shigella diarrhea. I. Enterotoxin production by Shigella dysenteriae I.志贺氏菌腹泻的发病机制。一、痢疾志贺氏菌I型产生肠毒素。
J Clin Invest. 1972 May;51(5):1212-8. doi: 10.1172/JCI106915.
6
The association between idiopathic hemolytic uremic syndrome and infection by verotoxin-producing Escherichia coli.特发性溶血尿毒综合征与产志贺毒素大肠杆菌感染之间的关联。
J Infect Dis. 1985 May;151(5):775-82. doi: 10.1093/infdis/151.5.775.
7
Colonic biopsy in verotoxin-induced hemorrhagic colitis and thrombotic thrombocytopenic purpura (TTP).
Am J Clin Pathol. 1986 Jul;86(1):108-12. doi: 10.1093/ajcp/86.1.108.
8
Pathogenesis of shigella diarrhea. XI. Isolation of a shigella toxin-binding glycolipid from rabbit jejunum and HeLa cells and its identification as globotriaosylceramide.志贺氏菌腹泻的发病机制。十一、从兔空肠和海拉细胞中分离出一种志贺氏菌毒素结合糖脂，并鉴定其为球三糖基神经酰胺。
J Exp Med. 1986 Jun 1;163(6):1391-404. doi: 10.1084/jem.163.6.1391.
9
Globotriosyl ceramide is specifically recognized by the Escherichia coli verocytotoxin 2.球形三糖神经酰胺被大肠杆菌志贺毒素2特异性识别。
Biochem Biophys Res Commun. 1988 Apr 29;152(2):674-9. doi: 10.1016/s0006-291x(88)80091-3.
10
Site of action of a Vero toxin (VT2) from Escherichia coli O157:H7 and of Shiga toxin on eukaryotic ribosomes. RNA N-glycosidase activity of the toxins.大肠杆菌O157:H7的维罗毒素（VT2）和志贺毒素在真核核糖体上的作用位点。毒素的RNA N-糖苷酶活性。
Eur J Biochem. 1988 Jan 15;171(1-2):45-50. doi: 10.1111/j.1432-1033.1988.tb13756.x.
Zotero 插件