Kawakami N, Araki S, Ohtsu H, Hayashi T, Masumoto T, Yokoyama K
Department of Public Health, Faculty of Medicine, University of Tokyo, Japan.
Ind Health. 1995;33(4):153-62. doi: 10.2486/indhealth.33.153.
To know the association between psychological strain and glycosylated hemoglobin (HbA1c) and to examine roles of smoking and catecholamine excretion as a possible mediator in the association, we measured mood states (Profile of Mood States, POMS), urinary catecholamines (adrenalin, noradrenaline and dopamine) from urine sample in early morning, HbA1c and fasting plasma glucose (FPG) of 63 male employees on a rest day. After excluding 12 subjects who had diabetes or impaired glucose tolerance or had missing response to the questionnaire, data from 51 subjects were analyzed. The POMS anger-hostility score significantly and positively correlated with HbA1c (p < 0.05), while other scale scores did not (p > 0.05). Number of cigarettes smoked per day significantly and positively correlated with HbA1c (p < 0.05). Urinary excretion rate of any catecholamine did not significantly correlate with HbA1c (p > 0.05). Multiple linear regression analysis indicated that the anger-hostility score significantly correlated with HbA1c after controlling for number of cigarettes per day (p < 0.05). It is suggested that, among mood states, anger-hostility is associated with increased HbA1c. However, our study failed to find a mediating role of urinary catecholamines or smoking on the association between the mood and HbA1c.
为了解心理压力与糖化血红蛋白（HbA1c）之间的关联，并检验吸烟和儿茶酚胺排泄作为该关联中可能的中介因素所起的作用，我们在休息日测量了63名男性员工的情绪状态（情绪状态剖面图，POMS）、清晨尿样中的尿儿茶酚胺（肾上腺素、去甲肾上腺素和多巴胺）、HbA1c以及空腹血糖（FPG）。在排除12名患有糖尿病或糖耐量受损或对问卷无应答的受试者后，对51名受试者的数据进行了分析。POMS愤怒-敌意得分与HbA1c呈显著正相关（p < 0.05），而其他量表得分则无此关联（p > 0.05）。每日吸烟量与HbA1c呈显著正相关（p < 0.05）。任何儿茶酚胺的尿排泄率与HbA1c均无显著相关性（p > 0.05）。多元线性回归分析表明，在控制每日吸烟量后，愤怒-敌意得分与HbA1c仍呈显著相关（p < 0.05）。这表明，在情绪状态中，愤怒-敌意与HbA1c升高有关。然而，我们的研究未能发现尿儿茶酚胺或吸烟在情绪与HbA1c之间的关联中起到中介作用。
