Nakayama Y, Matsuda T
Department of Bioengineering, National Cardiovascular Center Research Institute, Osaka, Japan.
J Biomed Mater Res. 1995 Oct;29(10):1295-301. doi: 10.1002/jbm.820291017.
In this report we demonstrate a microprocessing method to prepare microporous polymer films by an excimer laser ablation technique, which may enable the fabrication of functional biomedical devices such as advanced artificial organs. The irradiation of a KrF excimer laser pulses (wave-length 248 nm; fluence 1 J/cm2 pulse) onto several polymer films was achieved by passing a laser pulse through an optical microscope, resulting in the formation of an etched pit on the irradiated surface due to ablative photodecomposition. The number of pulses and the micropositioning of the irradiation were precisely controlled by a computer-aided control unit. Minimal ablation was observed for polyethylene with very small absorption coefficient (alpha) at 248 nm. For polymers which absorbed the laser photons, the etch depth increased linearly with number of pulses. The etch depth per pulse decreased with an increase in alpha values. An excellent structural quality, with micron-order precision of an etched pit, was found for those polymers with larger alpha values, such as polyimide, segmented polyurethane, and polycarbonate.
在本报告中，我们展示了一种通过准分子激光烧蚀技术制备微孔聚合物薄膜的微加工方法，这可能有助于制造功能性生物医学装置，如先进的人工器官。通过使激光脉冲穿过光学显微镜，将KrF准分子激光脉冲（波长248nm；能量密度1J/cm²脉冲）照射到几种聚合物薄膜上，由于烧蚀光分解，在照射表面形成蚀刻坑。脉冲数和照射的微定位由计算机辅助控制单元精确控制。对于在248nm处吸收系数（α）非常小的聚乙烯，观察到最小的烧蚀。对于吸收激光光子的聚合物，蚀刻深度随脉冲数线性增加。每个脉冲的蚀刻深度随α值的增加而减小。对于α值较大的聚合物，如聚酰亚胺、嵌段聚氨酯和聚碳酸酯，发现蚀刻坑具有微米级精度的优异结构质量。
