Berkel H J
Section Cancer Control and Prevention, Louisiana State University Medical Center, Shreveport, USA.
J La State Med Soc. 1995 Oct;147(10):449-57.
Data from the population based cancer registry in Alberta, Canada as well as from the National Canadian Cancer registry were used to evaluate the outcome of oncologic treatment over the past 25 years. Age standardized incidence rates for all cancers combined, and for most individual cancer sites separately, show a continuous increase over time. Overall, the mortality rates have been increasing as well. Age specific trends in incidence and mortality show that, despite an increase in incidence rate, only in childhood cancers does a decrease in mortality exist. However, in patients aged 50 years or more at the time of the cancer diagnosis an increase in mortality was noted which actually exceeded the increase in incidence. Site specific analysis showed a decreasing trend in mortality for Hodgkin's disease, testicular cancer, stomach cancer, and melanoma (in females). A disturbingly increasing trend, specifically in women, existed for lung cancer mortality. It is projected that in women in Alberta mortality from lung cancer will surpass breast cancer mortality to become the number one cancer killer in women within the next few years. The overall 1-year, 2-year, and 5-year relative survival for all cancers combined remained constant over the 25-year period covered in this study. In conclusion, when analyzing the three indicators (incidence, mortality, and survival rates) of success in the fight against cancer no objective signs of progress could be found. Exceptions are the childhood cancers and relatively infrequent tumors such as Hodgkin's disease and testicular cancer. A plea is made for a shift in funding towards an increased emphasis on applied prevention programs and research.
来自加拿大艾伯塔省基于人群的癌症登记处以及加拿大国家癌症登记处的数据,被用于评估过去25年肿瘤治疗的结果。所有癌症合并以及大多数个别癌症部位的年龄标准化发病率随时间持续上升。总体而言,死亡率也一直在上升。发病率和死亡率的年龄特异性趋势表明,尽管发病率有所上升,但仅儿童癌症的死亡率有所下降。然而,在癌症诊断时年龄为50岁及以上的患者中,死亡率上升,实际上超过了发病率的上升。特定部位分析显示,霍奇金淋巴瘤、睾丸癌、胃癌和黑色素瘤(女性)的死亡率呈下降趋势。肺癌死亡率存在令人不安的上升趋势,尤其是在女性中。预计在艾伯塔省女性中,肺癌死亡率将超过乳腺癌死亡率,在未来几年成为女性头号癌症杀手。在本研究涵盖的25年期间,所有癌症合并的总体1年、2年和5年相对生存率保持不变。总之,在分析抗癌斗争成功的三个指标(发病率、死亡率和生存率)时,未发现客观的进展迹象。儿童癌症以及霍奇金淋巴瘤和睾丸癌等相对罕见的肿瘤除外。呼吁将资金转向更加强调应用预防项目和研究。