Schneider W
Folia Haematol Int Mag Klin Morphol Blutforsch. 1978;105(5):700-5.
While cellular components have a relatively short half-life, must be necessarily administered group-specifically and kept available on a round-the-clock basis, all of which add significantly to the basic cost per unit, products isolated from plasma are not handicapped by these disadvantages. Another important advantage for the production of plasma components lies in the fact that the raw material may be also collected through plasmapheresis, a process which allows the collection of significantly greater amounts of plasma from one donor as compared to conventional whole blood collection. Quite understandably, the maintenance of whole blood and cellular component supplies has been left to national and/or non-profit organizations, while commercial firms run a profitable business with the production and distribution of plasma fractions. The method for the selective isolation of plasma fractions developed in our blood transfusion service solves the high cost problems involved in conventional fractionation methods but does not solve the ethical and economical problem related to discarding precious unused raw material.
虽然细胞成分的半衰期相对较短，必须按特定血型给药且需全天候供应，所有这些都显著增加了单位基本成本，但从血浆中分离出的产品不存在这些缺点。生产血浆成分的另一个重要优势在于，原材料也可以通过血浆置换术采集，与传统的全血采集相比，该过程能从一个供体采集到数量多得多的血浆。可以理解的是，全血和细胞成分供应的维持工作已交由国家和/或非营利组织负责，而商业公司则通过生产和销售血浆成分来盈利。我们输血服务机构开发的选择性分离血浆成分的方法解决了传统分馏方法涉及的高成本问题，但没有解决与丢弃珍贵未使用原材料相关的伦理和经济问题。
