Cubeddu R, Canti G, Taroni P, Valentini G
CEQSE-CNR, Politecnico di Milano, Italy.
J Photochem Photobiol B. 1995 Sep;30(1):23-7. doi: 10.1016/1011-1344(95)07157-w.
The potential of protoporphyrin IX fluorescence induced by the systemic administration of delta-aminolevulinic acid (ALA) for the detection of tumours was tested in three different murine models (MS-2 fibrosarcoma, L1210 leukaemia, and Lewis lung carcinoma). Time-gated fluorescence images were acquired up to 4 h after the intraperitoneal injection of ALA (200 mg (kg body mass (BM))-1). For comparison images were acquired also after the administration of 25 mg (kg BM)-1 of haematoporphyrin derivative. The latter drug was characterized by better localization in the tumour area, leading to higher fluorescence contrast between neoplastic mass and surrounding healthy tissue, and consequently was preferable for tumour diagnosis in all the models under study.
通过对三种不同的小鼠模型（MS-2纤维肉瘤、L1210白血病和Lewis肺癌）进行测试，探究了全身给药δ-氨基乙酰丙酸（ALA）诱导的原卟啉IX荧光用于肿瘤检测的潜力。在腹腔注射ALA（200 mg·kg体重-1）后长达4小时内采集时间分辨荧光图像。作为对照，在给予25 mg·kg体重-1的血卟啉衍生物后也采集了图像。后一种药物在肿瘤区域的定位更好，导致肿瘤块与周围健康组织之间的荧光对比度更高，因此在所有研究的模型中，它更适合用于肿瘤诊断。
