Punnonen K, Lehtola K, Autio P, Kiistala U, Ahotupa M
Department of Clinical Chemistry, University Central Hospital of Turku, Finland.
J Photochem Photobiol B. 1995 Sep;30(1):43-8. doi: 10.1016/1011-1344(95)07131-k.
In order to study the effects of repeated UVB exposures on the epidermal antioxidant defence system, we obtained epidermis samples from male volunteers who were exposed to chronic UVB irradiation. Chronic UVB irradiation was shown to be accompanied by induction of epidermal superoxide dismutase (SOD) activity in vivo, while the activities of the other antioxidant enzymes were not significantly changed. The repeated exposure of the epidermis to UVB irradiation was not accompanied by accumulation of products of lipid peroxidation reactions. As superoxide dismutase is of major importance in scavenging the reactive oxygen species, the UVB-induced changes in SOD activity might provide the epidermis a way of defending itself against the effects of chronic UVB irradiation.
为了研究重复紫外线B（UVB）照射对表皮抗氧化防御系统的影响，我们从接受慢性UVB照射的男性志愿者身上获取了表皮样本。结果显示，慢性UVB照射在体内会诱导表皮超氧化物歧化酶（SOD）活性，而其他抗氧化酶的活性没有明显变化。表皮反复暴露于UVB照射并未伴随脂质过氧化反应产物的积累。由于超氧化物歧化酶在清除活性氧方面至关重要，UVB诱导的SOD活性变化可能为表皮提供了一种抵御慢性UVB照射影响的自我防御方式。
