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Phosphorylation of caldesmon by mitogen-activated protein kinase with no effect on Ca2+ sensitivity in rabbit smooth muscle.

作者信息

Nixon G F, Iizuka K, Haystead C M, Haystead T A, Somlyo A P, Somlyo A V

机构信息

Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville 22908, USA.

出版信息

J Physiol. 1995 Sep 1;487 ( Pt 2)(Pt 2):283-9. doi: 10.1113/jphysiol.1995.sp020879.

DOI:10.1113/jphysiol.1995.sp020879
PMID:8558463
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1156572/
Abstract
  1. Recombinant, activated mitogen-activated protein kinase (3.3 microM; p42mapk) phosphorylated caldesmon in phasic (rabbit portal vein) and tonic (rabbit femoral artery) smooth muscle strips permeabilized with Triton X-100. 2. Phosphorylation of caldesmon by p42mapk neither induced contraction of relaxed smooth muscle nor affected the Ca2+ sensitivity of submaximally contracted permeabilized phasic or tonic smooth muscle.
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86e6/1156572/ee9637050928/jphysiol00312-0010-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86e6/1156572/2b8f0dd8a52a/jphysiol00312-0008-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86e6/1156572/ee9637050928/jphysiol00312-0010-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86e6/1156572/2b8f0dd8a52a/jphysiol00312-0008-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86e6/1156572/ee9637050928/jphysiol00312-0010-a.jpg

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本文引用的文献

1
Identification of mitogen-activated protein kinase phosphorylation sequences in mammalian h-Caldesmon.
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2
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J Biol Chem. 1993 Apr 15;268(11):7958-64.
3
Smooth-muscle caldesmon phosphatase is SMP-I, a type 2A protein phosphatase.平滑肌钙调蛋白磷酸酶是SMP-I，一种2A型蛋白磷酸酶。
Biochem J. 1993 Jul 1;293 ( Pt 1)(Pt 1):35-41. doi: 10.1042/bj2930035.
血管平滑肌收缩机制及平滑肌疾病的药物治疗基础
Pharmacol Rev. 2016 Apr;68(2):476-532. doi: 10.1124/pr.115.010652.
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Cerebral artery signal transduction mechanisms: developmental changes in dynamics and Ca2+ sensitivity.大脑动脉信号转导机制：动力学和 Ca2+敏感性的发育变化。
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Maturation and long-term hypoxia-induced acclimatization responses in PKC-mediated signaling pathways in ovine cerebral arterial contractility.PKC 介导的信号通路在绵羊脑血管收缩性中的成熟和长期低氧诱导适应反应。
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