Phosphorylation of caldesmon by mitogen-activated protein kinase with no effect on Ca2+ sensitivity in rabbit smooth muscle.
作者信息
Nixon G F, Iizuka K, Haystead C M, Haystead T A, Somlyo A P, Somlyo A V
机构信息
Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville 22908, USA.
出版信息
J Physiol. 1995 Sep 1;487 ( Pt 2)(Pt 2):283-9. doi: 10.1113/jphysiol.1995.sp020879.
Abstract
- Recombinant, activated mitogen-activated protein kinase (3.3 microM; p42mapk) phosphorylated caldesmon in phasic (rabbit portal vein) and tonic (rabbit femoral artery) smooth muscle strips permeabilized with Triton X-100. 2. Phosphorylation of caldesmon by p42mapk neither induced contraction of relaxed smooth muscle nor affected the Ca2+ sensitivity of submaximally contracted permeabilized phasic or tonic smooth muscle.
摘要
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